J. O. Raedler

Unravelling the metastasis-preventing effect of miR-200c in vitro and in vivo

This study shows that miR-200c expression reduces metastasis in vivo and inhibits cell migration in vitro in breast cancer models.

Nuclear deformation and dynamics of migrating cells in 3D confinement reveal adaptation of pulling and pushing forces

This study investigates how nuclear deformation and forces change in migrating cells under 3D confinement, revealing a shift from pulling to pushing mechanisms as channel width decreases.

Combining molecular dynamics simulations and X-ray scattering techniques for the accurate treatment of protonation degree and packing of ionizable lipids in monolayers

Self-Assembly of Tunable Intrinsically DisorderedPeptide Amphiphiles

This study investigates how sequence variations in IDPAs affect their self-assembly structures and phase transitions, showing that single amino acid mutations can tune mesophase behavior and enable enzymatic activation.

3D printed SAXS chamber for controlled in-situ dialysis and optical characterization

The paper introduces a 3D printed SAXS chamber enabling in-situ dialysis and optical characterization for studying responsive materials.

Nanoscale Organization of FasL on DNA Origami as a Versatile Platform to Tune Apoptosis Signaling in Cells

This paper demonstrates DNA origami nanoagents presenting FasL in defined geometries to control apoptosis signaling in cells, showing enhanced efficiency compared to soluble FasL.

Quasi-periodic migration of single cells on short microlanes

The paper studies quasi-periodic cell migration on microlanes and shows that a Cellular Potts model can recapitulate migration statistics with minimal cytoskeleton dynamics.

Area and Geometry Dependence of Cell Migration in Asymmetric Two-State Micropatterns

This study investigates how cell migration in asymmetric two-state micropatterns depends on area, shape, and orientation of adhesion sites, revealing occupancy probability ratios and transition rate dependencies.

Disentangling the Behavioural Variability of Confined Cell Migration

The paper quantifies cell migration variability in human breast cancer cells using a dynamical systems approach, revealing additional variance due to aging and population heterogeneity.