PRSS2 stimulates tumor growth by remodeling the TME via repression of Tsp1
L. Sui, S. Wang, D. Ganguly, T. El Rayes, C. Askeland, A. Borretzen, K. Zhou, D. Sim, O. J. Halvorsen, G. Knutsvik, S. Aziz, S. Haukaas, W. D. Foulkes, D. R. Bielenberg, A. Ziemys, , R. S. Watnick
This study identifies PRSS2 as a factor that represses Tsp-1 in the tumor microenvironment by binding to LRP1, promoting tumor growth.
bioRxiv · Mar 23, 2021 · PreprintCancer Biology