Author

S. Aziz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Cell Biology· 4 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 8 Research Focus:differential expression· 6 Assay:bulk RNA-seq· 5 Research Focus:cell type annotation· 5 Approach:experimental assay· 4 Research Focus:cancer & tumor microenvironment· 2 Approach:deep learning· 2 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

B. Arnholdt-Schmitt· 4 shared J. H. Costa· 4 shared C. Noceda· 3 shared L. A. Akslen· 3 shared C. Askeland· 2 shared D. R. Bielenberg· 2 shared D. Sim· 2 shared G. Knutsvik· 2 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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4 shared papersCell Biology

B. Arnholdt-Schmitt

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Bacterial pore-forming toxin pneumolysin drives pathogenicity through shed toxin-loaded host extracellular vesicles

S. Parveen, C. V. Bhat, S. Aziz, A. J, A. Dutta, S. Dutta, S. Show, K. Sharma, J. B. Johnson, U. Nongthomba, A. Banerjee, K. Subramanian

This study shows that pneumolysin-loaded host extracellular vesicles contribute to pneumococcal pathogenesis by inducing cytotoxicity and inflammation.

bioRxiv · Oct 12, 2023Microbiology

Allelic gene polymorphisms suspected to diversify the individual early metabolic response upon influenza H3N2 and SARS-CoV-2 infections

B. Arnholdt-Schmitt, S. Aziz, J. H. Costa

The paper identifies time-dependent transcript levels of polymorphic ASMTL genes in human nasal epithelial cells during influenza H3N2 and SARS-CoV-2 infections, suggesting potential allelic targets for early metabolic response prediction.

bioRxiv · May 5, 2022Cell Biology

Single-cell mapping links neurogenesis and angiogenesis in aggressive breast cancer

E. Wik, S. Aziz, K. Finne, D. Kleftogiannis, C. Askeland, G. Knutsvik, I. Winge, K. Kruger, A. A. Svanoe, E. Birkeland, S. Kjolle, B. Davidsen, T. Aas, I. M. Stefansson, H. Vethe, L. A. Akslen

The paper links neurogenesis and angiogenesis in aggressive breast cancer using single-cell spatial mapping and multi-omics data, showing a neuro-angiogenic signature associated with poor prognosis.

bioRxiv · Jan 28, 2022 · PreprintCancer Biology

Major complex trait for early de novo programming 'CoV-MAC-TED' detected in human nasal epithelial cells infected by two SARS-CoV-2 variants is promising for designing therapeutic strategies

J. H. Costa, S. Aziz, B. Arnholdt-Schmitt, C. Noceda

The paper identifies CoV-MAC-TED as a key metabolic trait in SARS-CoV-2 infected nasal epithelial cells and shows its relevance for anti-viral strategy development.

bioRxiv · Oct 19, 2021Cell Biology

Transcriptome data from human nasal epithelial cells infected by H3N2 influenza virus indicate early unbalanced ROS/RNA levels, temporarily increased aerobic fermentation linked to enhanced α-tubulin and rapid energy-dependent IRF9-marked immunization

J. H. Costa, S. Aziz, B. Arnholdt-Schmitt, C. Noceda

The paper examines transcriptome changes in human nasal epithelial cells infected with H3N2 influenza virus, identifying early ROS/RNS imbalance, increased glycolysis, and α-tubulin expression linked to energy-dependent immunization.

bioRxiv · Oct 18, 2021 · PreprintCell Biology

ROS/RNS balancing, aerobic fermentation regulation and cell cycle control a complex early trait ('CoV-MAC-TED') for combating SARS-CoV-2-induced cell reprogramming

J. H. Costa, G. Mohanapriya, B. Revuru, C. Noceda, K. L. L. Thiers, S. Aziz, S. Srivatsava, M. Oliveira, K. J. Gupta, A. Kumari, D. Sircar, S. R. Kumar, A. Achra, R. Sathishkumar, A. Adhloeya, B. Arnholdt-Schmitt

The paper identifies a complex trait, CoV-MAC-TED, linked to SARS-CoV-2-induced cell reprogramming through unbalanced ROS/RNS levels and aerobic fermentation.

bioRxiv · Jun 8, 2021Cell Biology

PRSS2 stimulates tumor growth by remodeling the TME via repression of Tsp1

L. Sui, S. Wang, D. Ganguly, T. El Rayes, C. Askeland, A. Borretzen, K. Zhou, D. Sim, O. J. Halvorsen, G. Knutsvik, S. Aziz, S. Haukaas, W. D. Foulkes, D. R. Bielenberg, A. Ziemys, , R. S. Watnick

This study identifies PRSS2 as a factor that represses Tsp-1 in the tumor microenvironment by binding to LRP1, promoting tumor growth.

bioRxiv · Mar 23, 2021 · PreprintCancer Biology

Feasibility of Integrating Canine Olfaction with Chemical and Microbial Profiling of Urine to Detect Lethal Prostate Cancer

C. Guest, R. Harris, K. S. Sfanos, E. Shrestha, A. W. Partin, B. Trock, L. Mangold, R. Bader, A. Kozak, S. Mclean, J. Simons, H. Soule, T. Johnson, W.-Y. Lee, Q. Gao, , A. Mershin

This study tests the feasibility of using canine olfaction, VOC analysis, and microbial profiling in urine to detect lethal prostate cancer, showing 71% sensitivity and 70-76% specificity.

bioRxiv · Sep 9, 2020Cancer Biology

Notch1 regulates breast cancer stem cell function via a non-canonical cleavage-independent pathway

L. Sui, S. Wang, R. K. Rodriguez, D. Sim, N. Bhattacharya, A. L. Blois, T. Schlaeger, S. Chen, S. Aziz, M. S. Rogers, D. R. Bielenberg, L. A. Akslen, R. S. Watnick

This study identifies a non-canonical Notch1 pathway that represses SIRT1 to drive tumor initiation and chemoresistance in breast cancer stem cells.

bioRxiv · Feb 28, 2020 · PreprintCancer Biology