L. Sui

The segmented flavivirus Alongshan virus reduces mitochondrial mass via degrading STAT2 to suppress innate immune response

Permanent Neonatal diabetes-causing Insulin mutations have dominant negative effects on beta cell identity

This study investigates two INS mutations causing permanent neonatal diabetes, showing they impair beta cell function through misfolded proinsulin, ER stress, and dedifferentiation.

Extensive diversity of RNA viruses in ticks revealed by metagenomics in northeastern China

The paper uses metagenomics to identify 22 RNA viruses in ticks from northeastern China, revealing novel species and highlighting public health risks from emerging tick-borne viruses.

Flavivirus prM interacts with MDA5 and MAVS to inhibit RLR antiviral signaling

This study identifies how flavivirus prM proteins interact with MDA5 and MAVS to inhibit RLR antiviral signaling, revealing species-dependent immune evasion mechanisms.

Cyb5r3-based mechanism and reversal of secondary failure to sulfonylurea

This study identifies Cyb5r3 downregulation as a mechanism of sulfonylurea failure and shows that a Cyb5r3 activator can reverse this failure in an animal model.

Use of Induced Pluripotent Stem Cells to Build Isogenic Systems and Investigate Type 1 Diabetes

This paper demonstrates the use of induced pluripotent stem cells to create an isogenic system for studying genetic influences on cell-cell interactions in type 1 diabetes.

PRSS2 stimulates tumor growth by remodeling the TME via repression of Tsp1

This study identifies PRSS2 as a factor that represses Tsp-1 in the tumor microenvironment by binding to LRP1, promoting tumor growth.

SARS-CoV-2 nucleocapsid protein dually regulates innate immune responses

This study shows that SARS-CoV-2 N protein modulates innate immunity by both suppressing and promoting IFN-I and inflammatory responses depending on its dosage.

Regulation of intracellular signaling and neuron function by Bardet-Biedl Syndrome proteins in patient-specific iPSC-derived neurons

This study investigates how BBS mutations affect neuron function and signaling in iPSC-derived neurons, identifying impaired ciliary function and signaling pathways related to energy homeostasis.

Identification of a new orthonairovirus associated with human febrile illness in China

This study identifies a new orthonairovirus, SGLV, associated with human febrile illness in northeastern China, showing its presence in ticks and clinical symptoms in infected patients.

Establishing cell-intrinsic limitations in cell cycle progression controls graft growth and promotes differentiation of pancreatic endocrine cells

The paper investigates how limitations in S-phase progression affect pancreatic endocrine differentiation and graft growth, finding that impaired DNA replication enhances differentiation and prevents cystic growth.

Notch1 regulates breast cancer stem cell function via a non-canonical cleavage-independent pathway

This study identifies a non-canonical Notch1 pathway that represses SIRT1 to drive tumor initiation and chemoresistance in breast cancer stem cells.

Active Trachoma Cases In The Solomon Islands Have Varied Polymicrobial Community Structures But Do Not Associate With Individual Non-Chlamydial Pathogens Of The Eye

The paper investigates whether active trachoma in the Solomon Islands is linked to non-chlamydial pathogens or polymicrobial dysbiosis, finding no significant association with individual pathogens but noting inter-individual microbiome variation.