Human plasma cells engineered to secrete bispecifics drive effective in vivo leukemia killing
T. F. Hill, P. Narvekar, G. Asher, N. Camp, K. R. Thomas, S. K. Tasian, D. J. Rawlings, R. G. James
This paper engineers human plasma cells to secrete bispecific antibodies that kill leukemia cells in vitro and in vivo, showing efficacy against B-acute lymphoblastic leukemia and acute myeloid leukemia.
bioRxiv · Aug 24, 2023 · PreprintBioengineering