Author

R. G. James

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Organism:human· 2 Organism:non-human primate· 2 Assay:scRNA-seq· 2 Research Focus:drug response / drug discovery· 1 Assay:flow cytometry· 1 Assay:proteomics· 1

Frequent Co-Authors

D. J. Rawlings· 4 shared R. Y.-H. Cheng· 3 shared C. Lopez· 2 shared N. Dahl· 2 shared R. Soligalla· 2 shared S. Kreuser· 2 shared Y. Honaker· 2 shared A. R. Ott· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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4 shared papersBioengineering

D. J. Rawlings

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Advancing Cell Therapies: Single-Cell Profiling, Generation, Expansion, and Gene Delivery in Rhesus Macaque Plasma B Cells

R. Y.-H. Cheng, S. Kreuser, N. Dahl, Y. Honaker, R. Soligalla, C. Lopez, D. J. Rawlings, R. G. James

This study expands NHP B cells ex vivo, identifies unique plasma cell markers, and establishes AAV transduction conditions for engineered B cell therapies.

bioRxiv · Oct 29, 2023 · PreprintBioengineering

Human plasma cells engineered to secrete bispecifics drive effective in vivo leukemia killing

T. F. Hill, P. Narvekar, G. Asher, N. Camp, K. R. Thomas, S. K. Tasian, D. J. Rawlings, R. G. James

This paper engineers human plasma cells to secrete bispecific antibodies that kill leukemia cells in vitro and in vivo, showing efficacy against B-acute lymphoblastic leukemia and acute myeloid leukemia.

bioRxiv · Aug 24, 2023 · PreprintBioengineering

SEC-seq: Association of molecular signatures with antibody secretion in thousands of single human plasma cells

R. Y.-H. Cheng, J. de Rutte, A. R. Ott, L. Bosler, W.-Y. Kuo, J. Liang, B. E. Hall, D. J. Rawlings, D. Di Carlo, R. G. James

The paper introduces SEC-seq, a method to link antibody secretion with surface markers and transcriptomes in single human plasma cells, revealing pathways associated with high IgG secretion.

bioRxiv · Aug 25, 2022Bioengineering

Efficient methods for generation and expansion of, and gene delivery to Rhesus Macaque plasma B cells

S. Kreuser, Y. Honaker, R. Y.-H. Cheng, N. Dahl, R. Soligalla, C. Lopez, D. J. Rawlings, R. G. James

The paper develops methods to expand and transduce rhesus macaque B cells for potential cell therapy applications.

bioRxiv · Sep 30, 2021 · PreprintImmunology