C. Fernandez

Structural basis of dual BACH1 regulation by SCFFBXO22 and SCFFBXL17

This study elucidates how BACH1 is regulated by SCFFBXO22 and SCFFBXL17 through structural changes in FBXO22 and modifications in BACH1's BTB domain, affecting its ubiquitylation and stability.

Nuclear RNAi Modulates Influenza A Virus Infectivity By Downregulating Type-I Interferon Response

This study shows that influenza A virus exploits nuclear RNAi by inducing AGO2 accumulation and silencing type-I interferon genes, and that arsenic trioxide can counteract this effect.

Loss of Lamin A leads to the nuclear translocation of AGO2 and compromised RNA interference

This study shows that loss of Lamin A causes AGO2 to move into the nucleus, impairing RNAi and increasing oncogenic miRNA expression in cancer cells.

Impact of Phosphorylation on the Physiological Form of Human alpha-Synuclein in Aqueous Solution

This study uses molecular simulations to investigate how phosphorylation at serine 129 affects the structure of human alpha-synuclein in aqueous solution, finding no significant impact on its conformational ensemble.

Leaf metabolic traits reveal hidden dimensions of plant form and function

The paper analyzes leaf metabolome variation across plant species to identify metabolic functional traits that reveal new dimensions of plant form and function.

Intercellular transmission of a bacterial cytotoxic prion-like protein in mammalian cells

The paper demonstrates horizontal transmission of a bacterial prion-like protein in mammalian cells, showing amyloid cross-aggregation and toxicity similar to bacterial systems.

Resting networks and personality predict attack speed in social spiders

The paper examines how resting social network structures and individual boldness traits predict attack speed in social spiders, finding that network position and boldness interact to influence collective predation behavior.

Conformational Priming of RepA-WH1 for Functional Amyloid Conversion Detected by NMR Spectroscopy

This study uses NMR spectroscopy to investigate conformational changes in RepA-WH1 that enable its transition to an amyloid state, revealing the role of structural dynamics and ligand binding.