Mutators drive evolution of multi-resistance to antibiotics
D. R. Gifford, E. Berrios-Caro, C. Joerres, M. Sune, J. Forsyth, A. Bhattacharyya, T. Galla, C. G. Knight
This study shows that mutator bacteria can evolve multi-drug resistance under both single-drug and combination antibiotic treatments, undermining the effectiveness of combination therapy.
bioRxiv · Sep 10, 2022 · PreprintEvolutionary Biology