Author

C. G. Knight

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 5 Microbiology· 2 Physiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 4 Organism:E. coli· 3 Approach:statistical model· 3 Research Focus:chromatin & epigenetic regulation· 2 Organism:rat· 2 Organism:bacteria (other)· 1 Assay:behavioral assay· 1

Frequent Co-Authors

D. R. Gifford· 3 shared R. Krasovec· 3 shared A. Bhattacharyya· 2 shared J. Reimer· 2 shared A. Channon· 1 shared A. Geim· 1 shared A. J. McBain· 1 shared A. McBain· 1 shared

Activity by Year

2017-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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3 shared papersEvolutionary Biology

D. R. Gifford

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Elevated mutation rates in the multi-azole resistant Aspergillus fumigatus cladedrives rapid evolution of antifungal resistance

M. J. Bottery, N. J. van Rhijn, H. Chown, J. L. Rhodes, B. N. Celia-Sanchez, M. T. Brewer, M. Momany, M. C. Fisher, C. G. Knight, M. J. Bromley

This study identifies a mutation rate increase in a multi-azole resistant Aspergillus fumigatus clade, linking it to rapid antifungal resistance evolution.

bioRxiv · Dec 5, 2023 · PreprintMicrobiology

Working together to control mutation: how collective peroxide detoxification determines microbial mutation rate plasticity

R. Green, H. Wang, C. Botchey, N. Zhang, C. Wadsworth, A. McBain, P. Paszek, R. Krasovec, C. G. Knight

This study identifies hydrogen peroxide detoxification as the mechanism behind density-dependent mutation rate plasticity in microbial populations.

bioRxiv · Sep 27, 2023Evolutionary Biology

Environmental and genetic influence on rate and spectrum of spontaneous mutations in Escherichia coli

D. R. Gifford, A. Bhattacharyya, A. Geim, E. Marshall, R. Krasovec, C. G. Knight

This study investigates how environmental and genetic factors influence the mutation rate and spectrum in Escherichia coli, revealing distinct mutation patterns under different glucose conditions.

bioRxiv · Apr 6, 2023 · PreprintEvolutionary Biology

Mutators drive evolution of multi-resistance to antibiotics

D. R. Gifford, E. Berrios-Caro, C. Joerres, M. Sune, J. Forsyth, A. Bhattacharyya, T. Galla, C. G. Knight

This study shows that mutator bacteria can evolve multi-drug resistance under both single-drug and combination antibiotic treatments, undermining the effectiveness of combination therapy.

bioRxiv · Sep 10, 2022 · PreprintEvolutionary Biology

Horizontal gene transfer increases microbiome stability

K. Z. Coyte, C. Stevenson, C. G. Knight, E. Harrison, J. P. J. Hall, M. A. Brockhurst

This study shows that horizontal gene transfer increases microbiome stability by spreading resistance genes, but affects individual taxa differently based on gene mobility and community interactions.

bioRxiv · Feb 25, 2022 · PreprintEvolutionary Biology

Intraperitoneal injection of sodium pentobarbital is associated with pain in rats.

J. Reimer, C. Schuster, C. G. Knight, D. Pang, V. S. Leung

This study assesses pain associated with intraperitoneal sodium pentobarbital injection in rats using behavioral metrics and finds signs of pain despite sedative effects.

bioRxiv · Jul 15, 2019 · PreprintPhysiology

Prototheca zopfii Genotype II induces mitochondrial apoptosis in models of bovine mastitis

M. Shahid, E. R. Cobo, L. Chen, P. A. Cavalcante, H. W. Barkema, J. Gao, S. Xu, Y. Liu, C. G. Knight, J. P. Kastelic, B. Han

This paper investigates how Prototheca zopfii genotype II causes mitochondrial apoptosis and inflammation in bovine mastitis models.

bioRxiv · Feb 27, 2019Microbiology

Opposing effects of population density and stress on Escherichia coli mutation rate

R. Krasovec, H. Richards, D. R. Gifford, R. V. Belavkin, A. Channon, E. Aston, A. J. McBain, C. G. Knight

This study shows that population density and stress have opposing effects on mutation rates in Escherichia coli, with mutation rates minimized at intermediate nutrient levels.

bioRxiv · Jan 30, 2018Evolutionary Biology

Refinement of intraperitoneal injection of sodium pentobarbital for euthanasia inlaboratory rats (Rattus norvegicus)

K. Zatroch, C. G. Knight, J. Reimer, D. S. Pang

This study refines intraperitoneal pentobarbital euthanasia in rats by testing different doses and volumes, finding that higher doses reduce time to death and variability, while increasing volume alone does not significantly reduce variability.

BMC Veterinary Research · Feb 21, 2017Peer-reviewedPhysiology