Author

D. R. Gifford

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 4 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:E. coli· 2 Research Focus:host-pathogen & immune response· 2 Approach:statistical model· 2 Organism:bacteria (other)· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

C. G. Knight· 3 shared A. Bhattacharyya· 2 shared E. Berrios-Caro· 2 shared R. Krasovec· 2 shared T. Galla· 2 shared A. Channon· 1 shared A. Geim· 1 shared A. J. McBain· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersEvolutionary Biology

C. G. Knight

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Author profile →

5 papers

Recent·Most cited

Antibiotic resistance alters the ability of Pseudomonas aeruginosa to invade the respiratory microbiome

S. Lindon, S. Shah, D. R. Gifford, M. A. Gomis Font, D. Kaur, A. Oliver, R. C. MacLean, R. M. Wheatley

This study shows antibiotic resistance in Pseudomonas aeruginosa can both help and hinder its ability to invade respiratory microbiomes, depending on the commensal microbes involved.

bioRxiv · Nov 14, 2023 · PreprintMicrobiology

Environmental and genetic influence on rate and spectrum of spontaneous mutations in Escherichia coli

D. R. Gifford, A. Bhattacharyya, A. Geim, E. Marshall, R. Krasovec, C. G. Knight

This study investigates how environmental and genetic factors influence the mutation rate and spectrum in Escherichia coli, revealing distinct mutation patterns under different glucose conditions.

bioRxiv · Apr 6, 2023 · PreprintEvolutionary Biology

Mutators drive evolution of multi-resistance to antibiotics

D. R. Gifford, E. Berrios-Caro, C. Joerres, M. Sune, J. Forsyth, A. Bhattacharyya, T. Galla, C. G. Knight

This study shows that mutator bacteria can evolve multi-drug resistance under both single-drug and combination antibiotic treatments, undermining the effectiveness of combination therapy.

bioRxiv · Sep 10, 2022 · PreprintEvolutionary Biology

Competition delays multi-drug resistance evolution during combination therapy

E. Berrios-Caro, D. R. Gifford, T. Galla

This study shows that competition between resistant strains affects the emergence of drug resistance, particularly for double resistance, and suggests that exponential growth models may overestimate resistance risks.

bioRxiv · May 27, 2020Evolutionary Biology

Opposing effects of population density and stress on Escherichia coli mutation rate

R. Krasovec, H. Richards, D. R. Gifford, R. V. Belavkin, A. Channon, E. Aston, A. J. McBain, C. G. Knight

This study shows that population density and stress have opposing effects on mutation rates in Escherichia coli, with mutation rates minimized at intermediate nutrient levels.

bioRxiv · Jan 30, 2018Evolutionary Biology