Validation of a CRISPR/cas9-based technology platform for examining specific immune gene functions in an experimental murine model of IBD
R. Wang, S. Graham, N. Sun, D. McCarthy, R. Peng, J. Erickson, X. Zhu, M. A. Wurbel, R. Dunstan, N. Chung, E. Fiebiger, T. Ghayur, J. Gu
The paper validates a CRISPR/Cas9 platform for studying immune gene functions in a murine IBD model, demonstrating its utility for in vivo validation of therapeutic targets.
bioRxiv · Apr 26, 2019 · PreprintImmunology