R. Peng

Asymmetric Allostery in Estrogen Receptor-α Homodimers Drives Responses to the Ensemble of Estrogens in the Hormonal Milieu

This paper shows that estrogen receptor-α homodimers can function as conformational heterodimers, integrating different ligand signals to produce distinct agonist or antagonist activity profiles.

The Structure of the Drp1 Lattice on Membrane

This study determines the structure of Drp1 on lipid membranes, revealing a locally ordered lattice and conformational changes that suggest a ratchet mechanism for mitochondrial constriction.

Pneumatic Nano-Sieve for CRISPR-based Detection of Drug-resistant Bacteria

This paper introduces a nano-sieve device for MRSA purification and detection using CRISPR, achieving a 15x concentration factor and 100 CFU/mL LOD.

Superhydrophobic Rotation-Chip for Computer-Vision Identification of Drug-Resistant Bacteria

The paper introduces a microfluidic device called Rotation-Chip for detecting drug-resistant bacteria without external instruments, achieving high fluid transport efficiency and 100% computer vision accuracy.

Characterizing the Resolution and Throughput of the Apollo Direct Electron Detector

The paper evaluates the Apollo direct electron detector's performance in cryo-EM, showing high-resolution reconstructions across different dose rates and sample sizes.

Dissecting the genetic basis of the heterosis of Y900, an elite super-hybrid rice

The paper identifies genetic and regulatory mechanisms underlying heterosis in the rice hybrid Y900 by analyzing genome and transcriptome data from its parental lines.

ZBP1 induces inflammatory signaling via RIPK3 and promotes SARS-CoV-2-induced cytokine expression

This study identifies a ZBP1-RIPK1-RIPK3 pathway that promotes SARS-CoV-2-induced cytokine expression through inflammatory signaling independent of cell death.

Mechanism of hyperproteinemia-induced blood cell homeostasis imbalance in an animal model

This study investigates how hyperproteinemia disrupts blood cell homeostasis in an invertebrate model, identifying novel signaling pathways and potential biomarkers.

Tetratricopeptide repeat domain 36 protects renal tubular cells from cisplatin-induced apoptosis via maintaining mitochondrial homeostasis

This study shows TTC36 protects renal tubular cells from cisplatin-induced apoptosis by maintaining mitochondrial homeostasis and autophagy.

P4HA2-induced prolyl hydroxylation suppresses YAP1-mediated prostate cancer cell migration, invasion, and metastasis

This study identifies P4HA2-dependent prolyl hydroxylation of YAP1 as a suppressor of prostate cancer cell migration, invasion, and metastasis.

A Mycobacterium tuberculosis effector protein attacks host innate immunity by acting as an unusual ubiquitinating enzyme

This paper shows that Mtb PknG acts as an unusual ubiquitinating enzyme by promoting ubiquitination of TRAF2 and TAK1 to suppress host innate immunity.

Structural basis of SARS-CoV-2 polymerase inhibition by Favipiravir

This paper determines the cryo-EM structure of Favipiravir bound to SARS-CoV-2 polymerase, revealing its base-pairing mechanism and implications for antiviral drug development.

Structural and biochemical characterization of nsp12-nsp7-nsp8 core polymerase complex from COVID-19 virus

The paper determines the near-atomic structure of the SARS-CoV-2 polymerase complex and shows reduced activity and thermostability compared to SARS-CoV.

Transcriptomic and Proteomic Analyses of a New Cytoplasmic Male Sterile Line with wild Gossypium bickii. Genetic Background

The paper analyzes transcriptomic and proteomic data from a new cytoplasmic male sterile cotton line to identify differentially expressed genes and proteins involved in microspore abortion.

Validation of a CRISPR/cas9-based technology platform for examining specific immune gene functions in an experimental murine model of IBD

The paper validates a CRISPR/Cas9 platform for studying immune gene functions in a murine IBD model, demonstrating its utility for in vivo validation of therapeutic targets.