A Kink in DWORF Helical Structure Controls the Activation of the Sarco-plasmic Reticulum Ca2+-ATPase
V. U. Reddy, D. K. Weber, S. Wang, E. K. Larsen, T. Gopinath, A. De Simone, S. L. Robia, G. Veglia
This study determines the structure of DWORF and shows that a kink caused by Pro15 enables its unique activation of SERCA.
bioRxiv · May 5, 2021Biophysics