Author

G. Veglia

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:protein folding & dynamics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:mechanistic / dynamical model· 1 Assay:structural biology· 1

Frequent Co-Authors

A. De Simone· 2 shared C. Olivieri· 2 shared D. K. Weber· 2 shared E. K. Larsen· 2 shared S. S. Taylor· 2 shared S. Wang· 2 shared V. U. Reddy· 2 shared B. R. Myers· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersBiophysics

A. De Simone

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

The αC-β4 loop controls the allosteric cooperativity between nucleotide and substrate in the catalytic subunit of protein kinase A

C. Olivieri, Y. Wang, C. Walker, M. V. Subrahmanian, K. N. Ha, D. A. Bernlohr, J. Gao, C. Camilloni, M. Vendruscolo, S. S. Taylor, G. Veglia

This study identifies the αC-β4 loop as a key regulator of allosteric cooperativity between nucleotide and substrate in PKA-C through simulations and mutagenesis experiments.

eLife · Jun 24, 2024Peer-reviewedBiophysics

A PKA Inhibitor Motif within Smoothened Controls Hedgehog Signal Transduction

J. T. Happ, C. D. Arveseth, J. Bruystens, D. Bertinetti, I. B. Nelson, C. Olivieri, D. S. Hedeen, J.-F. Zhu, J. L. Capener, J. W. Bröckel, L. Vu, C. C. King, V. L. Ruiz-Perez, G. Veglia, F. W. Herberg, , B. R. Myers

This study identifies a PKA inhibitor motif in Smoothened that blocks PKA activity, enabling GLI activation in the Hedgehog pathway, revealing a mechanism similar to the Wnt cascade.

bioRxiv · Jul 5, 2021Biochemistry

A Kink in DWORF Helical Structure Controls the Activation of the Sarco-plasmic Reticulum Ca2+-ATPase

V. U. Reddy, D. K. Weber, S. Wang, E. K. Larsen, T. Gopinath, A. De Simone, S. L. Robia, G. Veglia

This study determines the structure of DWORF and shows that a kink caused by Pro15 enables its unique activation of SERCA.

bioRxiv · May 5, 2021Biophysics

Structural Basis for Allosteric Control of the SERCA-Phospholamban Membrane Complex by Ca2+ and cAMP-dependent Phosphorylation

D. K. Weber, M. S. Hernandez, V. U. Reddy, S. Wang, E. K. Larsen, G. Tata, M. Gustavsson, R. L. Cornea, D. D. Thomas, A. De Simone, G. Veglia

This study reveals how phosphorylation and Ca2+ modulate the SERCA-PLN complex through structural changes that enhance Ca2+ transport.

bioRxiv · Aug 28, 2020 · PreprintBiophysics