Pharmacology & ToxicologybioRxiv
Synthesis and structural optimization of 2,7,9-trisubstituted purin-8-ones as FLT3-ITD inhibitors
M. Tomanova, K. Kozlanska, R. Jorda…·V. Krystof
The paper designs and evaluates 2,7,9-trisubstituted purin-8-ones as FLT3-ITD inhibitors, identifying compound 15a with improved selectivity and activity in vitro and in vivo.