Author

G. Caravagna

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 6

Signature Assays, Organisms & Methods

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Organism:human· 6 Assay:whole-genome sequencing· 5 Approach:statistical model· 4 Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 3 Assay:ATAC-seq· 2 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2

Frequent Co-Authors

A. Sottoriva· 5 shared A.-M. Baker· 5 shared C. James· 5 shared J. Fernandez-Mateos· 5 shared M. Jansen· 5 shared B. Chen· 4 shared C. Kimberley· 4 shared D. Shibata· 4 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersCancer Biology

A. Sottoriva

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Epigenetic heritability of cell plasticity drives cancer drug resistance through one-to-many genotype to phenotype mapping

J. Fernandez-Mateos, S. Milite, E. Oliveira, G. Vlachogiannis, B. Chen, E. Yara, G. D. Cresswell, C. James, L. Patruno, G. Ascolani, A. Acar, T. Heide, I. Spiteri, A. Graudenzi, G. Caravagna, , A. Sottoriva

The paper shows how epigenetic heritability of cell plasticity contributes to cancer drug resistance through a one-to-many genotype-to-phenotype mapping.

bioRxiv · Nov 15, 2023 · PreprintCancer Biology

Phenotypic plasticity and genetic control in colorectal cancer evolution

J. Househam, T. Heide, G. D. Cresswell, C. Lynn, I. Spiteri, M. Mossner, C. Kimberley, C. Gabbutt, E. Lakatos, A. Berner, M. Schmidt, A.-M. Baker, J. Fernandez-Mateos, B. Chen, L. Zapata, , T. A. Graham

This study investigates phenotypic plasticity and genetic control in colorectal cancer by analyzing gene expression and genetic variation across multiple tumor regions.

Nature · Oct 26, 2022Peer-reviewedCancer Biology

The co-evolution of the genome and epigenome in colorectal cancer

T. Heide, J. Househam, I. Spiteri, C. Lynn, G. D. Cresswell, M. Mossner, C. Kimberley, J. Fernandez-Mateos, B. Chen, L. Zapata, C. James, I. Barozzi, K. Chkhaidze, D. Nichol, A. Berner, , A. Sottoriva

This study examines the co-evolution of genome and epigenome in colorectal cancer using single-clone spatial multi-omic profiling, revealing epigenetic changes and their impact on mutation accumulation.

Nature · Oct 26, 2022Peer-reviewedCancer Biology

Mutation Rate Evolution Drives Immune Escape In Mismatch Repair-Deficient Cancer

H. Kayhanian, P. Barmpoutis, E. Lakatos, W. C. H. Cross, G. Caravagna, L. Zapata, K. Litchfield, C. D. Steele, W. Waddingham, D. Patel, S. Milite, C. Jin, A.-M. Baker, C. Ross, D. Alexander, , M. Jansen

The paper shows that mutation rate adaptation in MMRd cancers drives immune escape by modulating neoantigen diversity and subclonal mutation rates.

bioRxiv · Mar 6, 2022 · PreprintCancer Biology

Assessment of the evolutionary consequence of putative driver mutations in colorectal cancer with spatial multiomic data

T. Heide, J. Househam, G. D. Cresswell, I. Spiteri, C. Lynn, C. Kimberley, M. Mossner, L. Zapata, C. Gabbutt, D. Ramazzotti, B. Chen, J. Fernandez-Mateos, C. James, F. Iorio, A. Berner, , A. Sottoriva

This study uses spatial multiomic data to assess the evolutionary impact of putative driver mutations in colorectal cancer, identifying both genetic and non-genetic factors influencing subclonal expansion.

bioRxiv · Jul 14, 2021 · PreprintCancer Biology

Negative selection may cause grossly altered but broadly stable karyotypes in metastatic colorectal cancer

W. Cross, S. Nowinski, G. Cresswell, M. Mossner, A. Banerjee, B. Lu, M. Williams, G. Vlachogiannis, L. Gay, A.-M. Baker, C. Kimberley, F. Whiting, H. Belnoue-Davis, P. Martinez, M. Traki, , Wat

This study analyzes longitudinal genomic data from colorectal cancer patients to show that negative selection stabilizes karyotypes during tumor progression and metastasis.

bioRxiv · Mar 26, 2020 · PreprintCancer Biology