MicroRNA-194 promotes lineage plasticity in advanced prostate cancer
R. C. Fernandes, J. Toubia, S. Townley, A. R. Hanson, B. K. Dredge, K. A. Pillman, A. G. Bert, R. Iggo, R. Das, MURAL investigators, D. Obinata, S. Sandhu, G. P. Risbridger, R. A. Taylor, M. G. Lawrence, , L. Selth
This study identifies miR-194 as a regulator of lineage plasticity in prostate cancer by targeting FOXA1 and promoting transdifferentiation to a neuroendocrine-like state.
bioRxiv · Sep 12, 2019 · PreprintCancer Biology