S. Nair

Yerba mate (Ilex paraguariensis) genome provides new insights into convergent evolution of caffeine biosynthesis

The paper reports the yerba mate genome, identifies a unique caffeine biosynthesis pathway, and reveals structural adaptations for convergent evolution of caffeine production.

Nuclear compression-mediated DNA damage drives ATR-dependent Lamin expression and mouse ESC differentiation

The paper shows that nuclear compression-induced DNA damage drives mESC differentiation via ATR-dependent Lamin A/C regulation.

Presence of phage-plasmids in multiple serovars of Salmonella enterica

This study identifies phage-plasmids in multiple Salmonella serovars, showing their prevalence and serovar-specific distribution, with implications for antimicrobial resistance transmission.

The Implant-Induced Foreign Body Response is Limited by CD13-Dependent Regulation of Ubiquitination of Fusogenic Proteins

This study shows CD13 regulates macrophage fusion by controlling ubiquitination of fusogenic proteins, limiting foreign body response fibrosis and suggesting CD13 as a therapeutic target.

CRISPR-Cas13d screens identify KILR a breast cancer risk-associated lncRNA that regulates DNA replication and repair.

The paper identifies KILR, a breast cancer risk-associated lncRNA, and shows it regulates DNA replication and repair by sequestering RPA1.

The origins of haplotype 58 (H58) Salmonella enterica serovar Typhi

This study traces the origin and spread of the H58 lineage of Salmonella Typhi, showing it emerged in India in 1987 as multi-drug resistant and later became globally prevalent.

Host network-based discovery of critical regulators of innate immunity, virus growth, and pathogenesis in influenza virus infection

The paper identifies novel innate immune regulators affecting influenza virus replication and pathogenesis through experimental validation of network model predictions.

Neuroinflammation in neuronopathic Gaucher disease: Role of microglia and NK cells

This study investigates neuroinflammation in neuronopathic Gaucher disease by examining microglia and NK cells in mouse models, showing that Gba rescue in these cells reduces neuroinflammation and improves survival.

Fitness costs of pfhrp2 and pfhrp3 deletions underlying diagnostic evasion in malaria parasites

The paper measures fitness costs of pfhrp2 and pfhrp3 deletions in malaria parasites using CRISPR/Cas9 and competition experiments, finding costs consistent with diagnostic selection driving their spread in some regions.

Donor monocyte-derived macrophages promote human acute graft versus host disease

The paper identifies donor monocyte-derived macrophages as key players in human acute graft versus host disease, showing their enhanced activation of T cells and secretion of inflammatory cytokines.

Mode and tempo of microsatellite length change in a malaria parasite mutation accumulation experiment

This study quantifies microsatellite mutation rates in malaria parasites, finding low rates influenced by repeat motif and array length, with most mutations involving multiple repeat changes.

A real-time PCR for the differentiation of typhoidal and non-typhoidal Salmonella

This paper develops a real-time PCR assay to rapidly and accurately differentiate typhoidal and non-typhoidal Salmonella with 100% sensitivity and specificity.

Informal genomic surveillance of regional distribution of Salmonella Typhi genotypes and antimicrobial resistance via returning travellers

This study uses whole-genome sequencing of Salmonella Typhi isolates from travelers to analyze genotype distribution and antimicrobial resistance patterns across regions.

Substrate-assisted Enzymatic Formation of Lysinoalanine in Duramycin

The paper investigates the mechanism of lysinoalanine formation in duramycin, showing that it is catalyzed by DurN through a substrate-assisted process involving Hya15 as a base.

Salmonella enterica Serovar Typhimurium ST313 Responsible For Gastroenteritis In The UK Are Genetically Distinct From Isolates Causing Bloodstream Infections In Africa

This paper identifies genetically distinct ST313 Salmonella isolates causing gastroenteritis in the UK and invasive disease in Africa, highlighting their evolutionary divergence and adaptation to different environments.

Millennia of genomic stability within the invasive Para C Lineage of Salmonella enterica

The study analyzes an 800-year-old Paratyphi C genome to show its origin from swine pathogens and its long history as a human pathogen.