T. Hussain

Yeast eukaryotic initiation factor 4B remodels the mRNA entry site on the small ribosomal subunit

This study uses cryo-electron microscopy to determine the position of yeast eIF4B on the 40S ribosomal subunit and its role in mRNA recruitment.

Nuclear pore complexes undergo Nup221 exchange during blood stage asexual replication of Plasmodium parasites.

This study uses U-ExM and RITE to show Nup221 turnover in P. berghei NPCs during blood-stage replication.

Atomic structure of wheat ribosome reveals unique features of the plant ribosomes

The paper presents high-resolution cryo-EM structures of wheat ribosomes and identifies unique features compared to other eukaryotes.

Knock-sideways by inducible ER retrieval enables anovel approach for studying Plasmodium secreted proteins

The paper introduces knockER, a method to conditionally sequester Plasmodium secreted proteins in the ER, enabling loss-of-function studies and sub-compartmental resolution of protein function.

The PTEX pore component EXP2 is important for intrahepatic development during the Plasmodium liver stage

This study uses a ribozyme-based approach to show EXP2 is essential for Plasmodium liver stage development, highlighting its role in the PTEX translocon at the hepatocyte-parasite interface.

Drug targeting Nsp1-ribosomal complex shows antiviral activity against SARS-CoV-2

This study identifies montelukast sodium hydrate as a potential antiviral drug against SARS-CoV-2 by targeting the Nsp1-ribosomal complex and reducing viral replication in cell cultures.

Selection of start codon during mRNA scanning in eukaryotic translation initiation

This study uses molecular dynamics simulations to show that the scanning conformation of the 48S PIC can accurately select start codons while rejecting most non-AUG codons.

Dietary Protein on Growth Performance, Serum Biochemical Index and offspring of Hu ewes in late pregnancy

This study examines the effects of different dietary protein levels on ewe growth, serum biochemistry, and lamb development during late pregnancy, finding no significant impact on growth performance but significant effects on metabolic indicators and lamb body measurements.

Prevalence, risk factors and health seeking behaviour of pulmonary tuberculosis in four tribal dominated districts of Odisha

The paper assesses TB prevalence, risk factors, and health-seeking behavior in tribal communities in Odisha, finding a 0.68% prevalence rate linked to cultural ignorance, alcohol use, and poor access to healthcare.

Translational initiation factor eIF5 replaces eIF1 on the 40S ribosomal subunit to promote start-codon recognition

The paper presents a cryo-EM structure of a 48S pre-initiation complex showing eIF5's role in promoting start-codon recognition by stabilizing the Met-tRNAi-codon interaction.