R. K. Mishra

Rho and a riboswitch regulate mntP expression evading manganese stress and membrane toxicity

The paper shows Rho terminates transcription at the mntP riboswitch, and manganese activates the riboswitch to restore transcription-translation coupling, preventing membrane toxicity from overexpressed MntP.

Atomic structure of wheat ribosome reveals unique features of the plant ribosomes

The paper presents high-resolution cryo-EM structures of wheat ribosomes and identifies unique features compared to other eukaryotes.

Biochemical deconstruction and reconstruction of Nuclear Matrix reveals the layers of nuclear organization

The paper deconstructs and reconstructs the Nuclear Matrix (NuMat) to reveal its organizational layers through biochemical fractionation and proteomic analysis.

Bird assemblages in a peri-urban landscape in eastern India

The paper surveys bird diversity across four habitat types in a peri-urban landscape, finding that cropland and wasteland support rich avian diversity and significant variation in species composition.

An intrinsic alkalization circuit turns on mntP-riboswitch under manganese stress in Escherichia coli

The paper shows that manganese stress in E. coli activates a circuit involving ammonia production and cytoplasmic alkalization, enhancing mntP-riboswitch activation to improve manganese tolerance.

Sofosbuvir and its tri-phosphate metabolite inhibit the RNA-dependent RNA polymerase activity of non-Structural protein 5 from the Kyasanur forest disease virus

B.1.617.3 SARS CoV-2 spike E156G/Δ157-158 mutations contribute to reduced neutralization sensitivity and increased infectivity

This study identifies spike mutations in B.1.617.3 SARS-CoV-2 variants that reduce neutralization sensitivity and increase infectivity.

In situ Nuclear Matrix preparation in Drosophila melanogaster and its use in studying the components of nuclear architecture

This paper introduces a protocol for in situ Nuclear Matrix preparation in Drosophila embryos and tissues, enabling the study of nuclear architecture in a biologically relevant 3D context.

Free spermidine evokes superoxide radicals that manifest toxicity

The paper shows that excess free spermidine generates superoxide radicals, causing toxicity in bacteria lacking the SpeG enzyme, while SpeG enables tolerance by neutralizing spermidine.

Implications of critical nodes-dependent unidirectional cross-talk between Plasmodium and Human SUMO

This study identifies critical residues in Plasmodium SUMO and Ubc9 that enable unidirectional cross-species interactions with human SUMOylation machinery, suggesting potential targets for antimalarial drugs.

Dry Swab Method of sample collection for SARS-CoV2 testing can be used for culturing virus

This study shows that SARS-CoV-2 can be cultured from dry swabs stored at room temperature or 4°C, comparable to traditional viral transport medium.

Exon Junction Complex dependent mRNA localization is linked to centrosome organization during ciliogenesis

The paper shows EJC-dependent mRNA localization to centrosomes affects ciliogenesis and mNSC division.

Overexpressed Nup88 stabilized through interaction with Nup62 promotes NFκB dependent pathways in cancer

The paper shows that overexpressed Nup88, stabilized by its interaction with Nup62, promotes NFκB-dependent pathways in head and neck cancer, enhancing cell proliferation and migration.

PDGFR alpha signaling in cardiac fibroblasts modulates quiescence, metabolism and self-renewal, and promotes anatomical and functional repair

This study investigates how PDGFR alpha signaling in cardiac fibroblasts affects quiescence, metabolism, and self-renewal, leading to improved heart repair after myocardial infarction.

ELYS coordinates NF-κB pathway dynamics during development in Drosophila

This study shows ELYS regulates NF-κB pathway dynamics during Drosophila development, and its misregulation causes apoptosis through sustained NF-κB nuclear accumulation.