T. Imamichi

Escherichia coli grown in cost-effective conical tubes produces more plasmid DNA

The paper compares plasmid yield from different bacterial growth tubes and finds that Oxford conical-polypropylene tubes produce 1.5-fold more plasmid DNA than other polypropylene tubes.

Interleukin-27-induced HIV-resistant dendritic cells suppress reveres transcription following virus entry in an SPTBN1, Autophagy, and YB-1 independent manner

This study shows that IL-27 induces HIV-resistant dendritic cells that suppress reverse transcription post-virus entry, independent of SPTBN1, autophagy, and YB-1.

The C-terminal domain of RNase H and the C-terminus amino acid residue regulate virus release and autoprocessing of a defective HIV-1 possessing M50I and V151I changes in integrase

This study identifies the C-terminal domains of RNase H and integrase as regulators of virus release and autoprocessing in a defective HIV-1 variant with specific mutations.

Interleukin-27 skews TNF-alpha-induced inflammatory microenvironment in keratinocytes

This study shows that high IL-27 counteracts low TNF-alpha-induced inflammation in keratinocytes by upregulating anti-inflammatory cytokines.

S100A8 and S100A9, biomarkers of SARS-Cov-2-infected patients, suppress HIV replication in primary macrophages

This study shows that S100A8 and S100A9 subunits inhibit HIV replication in macrophages but not T cells, despite their role in SARS-CoV-2 infection.

Natural Occurring Non-Synonymous Single Nucleotide Polymorphisms in Integrase and RNase H Regulate Assembly and Autoprocessing of HIV-1

This paper investigates the impact of 14 non-synonymous SNPs in HIV on viral fitness, finding that specific mutations in integrase and RNase H impair GagPol autoprocessing and replication.

siRNA containing a unique 5-nucleotide motif acts as a quencher of IFI16-mediated innate immune response

The paper shows that siRNA with a 5-nucleotide motif suppresses DNA-mediated IFN and cytokine signaling by inhibiting IFI16-DNA binding.