Niche-derived soluble DLK1 promotes glioma stemness and growth
E. S. Grassi, P. Jeannot, V. Pantazopoulou, T. J. Berg, A. Pietras
This study shows that astrocytes in the glioma microenvironment secrete DLK1 under stress, which promotes glioma stemness and tumor growth by stabilizing HIF-2alpha.
bioRxiv · Aug 20, 2020Cancer Biology