Author

M. Squatrito

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cancer & tumor microenvironment· 3 Organism:human· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

B. Oldrini· 3 shared C. Marques· 3 shared P. Kroon· 2 shared S. Rodriguez-Perales· 2 shared A. Curiel-Garcia· 1 shared A. Izzo· 1 shared A. Pietras· 1 shared D. Lindgren· 1 shared

Activity by Year

2017-2020 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersCancer Biology

B. Oldrini

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

NF1 regulates mesenchymal glioblastoma plasticity and aggressiveness through the AP-1 transcription factor FOSL1

C. Marques, T. Unterkircher, P. Kroon, A. Izzo, Y. Dramaretska, E. Kling, B. Oldrini, O. Schnell, S. Nelander, E. F. Wagner, L. Bakiri, G. Gargiulo, M. S. Carro, M. Squatrito

The paper identifies FOSL1 as a key regulator of mesenchymal glioblastoma subtype through NF1 modulation, showing its role in plasticity and aggressiveness.

bioRxiv · Nov 6, 2020Cancer Biology

MGMT genomic rearrangements contribute to chemotherapy resistance in gliomas

B. Oldrini, N. Vaquero-Siguero, Q. Mu, P. Kroon, Y. Zhang, M. Galan-Ganga, Z. Bao, Z. Wang, H. Liu, J. K. Sa, J. Zhao, H. Kim, S. Rodriguez-Perales, D.-H. Nam, R. G. Verhaak, , M. Squatrito

This study shows that MGMT genomic rearrangements cause TMZ resistance in gliomas and can be detected in exosomes as potential recurrence markers.

Nature Communications · Aug 4, 2020Peer-reviewedCancer Biology

The irradiated brain microenvironment supports glioma stemness and survival via astrocyte-derived Transglutaminase 2

T. J. Berg, C. Marques, V. Pantazopoulou, E. Johansson, K. von Stedingk, D. Lindgren, E. J. Pietras, T. Bergström, F. J. Swartling, V. Governa, J. Bengzon, M. Belting, H. Axelson, M. Squatrito, A. Pietras

This study shows that irradiated astrocytes promote glioma stemness and survival through TGM2, suggesting targeting this pathway could improve radiotherapy outcomes.

bioRxiv · Feb 12, 2020Cancer Biology

Somatic genome editing with the RCAS/TVA-CRISPR/Cas9 system for precision tumor modeling

B. Oldrini, A. Curiel-Garcia, C. Marques, V. Matia, O. Uluckan, R. Torres-Ruiz, S. Rodriguez-Perales, J. Huse, M. Squatrito

This paper develops a mouse model using RCAS/TVA-CRISPR/Cas9 for in vivo somatic genome editing to generate accurate cancer models.

bioRxiv · Aug 14, 2017Cancer Biology