Author

T. J. Klein

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1 Research Focus:development & morphogenesis· 1 Organism:Drosophila· 1

Frequent Co-Authors

K. Futrega· 2 shared M. R. Doran· 2 shared P. G. Robey· 2 shared C. Y. Chabu· 1 shared E. Music· 1 shared G. Valdka· 1 shared J.-Y. J. Lu· 1 shared P. Glazer· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersCell Biology

K. Futrega

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Micro-pellet culture reveals that bone marrow mesenchymal stromal cell (BMSC) chondrogenic induction is triggered by a single day of TGF-β1 exposure

K. Futrega, P. G. Robey, T. J. Klein, R. Crawford, M. R. Doran

This paper shows that a single day of TGF-β1 exposure triggers chondrogenic differentiation in BMSCs using micro-pellet cultures, revealing faster kinetics than previously observed with macro-pellets.

Communications Biology · Jan 4, 2021Peer-reviewedCell Biology

Cooperation between oncogenic Ras and p53 stimulates JAK/STAT non-cell autonomously to promote Ras tumor radioresistance

Y.-L. Dong, G. Valdka, J.-Y. J. Lu, V. Ahmad, T. J. Klein, P. Glazer, T. Xu, C. Y. Chabu

The paper shows that oncogenic Ras and p53 cooperation activates JAK/STAT non-cell autonomously in the tumor microenvironment, promoting radioresistance and tumor recurrence.

bioRxiv · Oct 5, 2020Cancer Biology

Characterisation of ovine bone marrow-derived stromal cells (oBMSC) and evaluation of chondrogenically induced micro-pellets for cartilage tissue repair in vivo

K. Futrega, E. Music, P. G. Robey, S. Gronthos, R. W. Crawford, S. Saifzadeh, T. J. Klein, M. R. Doran

This study characterizes ovine BMSC and evaluates their chondrogenic potential in micro-pellets for cartilage repair, finding that oBMSC micro-pellets failed to repair defects while oACh micro-pellets showed modest repair.

bioRxiv · May 15, 2020Bioengineering