Cooperation between oncogenic Ras and p53 stimulates JAK/STAT non-cell autonomously to promote Ras tumor radioresistance
Y.-L. Dong, G. Valdka, J.-Y. J. Lu, V. Ahmad, T. J. Klein, P. Glazer, T. Xu, C. Y. Chabu
The paper shows that oncogenic Ras and p53 cooperation activates JAK/STAT non-cell autonomously in the tumor microenvironment, promoting radioresistance and tumor recurrence.
bioRxiv · Oct 5, 2020Cancer Biology