T. J. Mitchison

Spatial control of Keratin 8 phosphorylation by Aurora B facilitates cytokinesis in cancer cells of epithelial origin

The paper shows Aurora B phosphorylates Keratin 8 at the cleavage furrow, facilitating its disassembly during cytokinesis in epithelial cancer cells.

Glycogen-dependent demixing of frog egg cytoplasm at increased crowding

The paper investigates how increased crowding affects cytoplasm demixing in Xenopus egg extracts, showing glycogen-rich phases form and are influenced by glycogen hydrolysis.

Chromatin Bridges, not Micronuclei, Activate cGAS after Drug-induced Mitotic Errors in Human Cells

The paper shows that chromatin bridges, not micronuclei, activate cGAS and induce IFN signaling after mitotic errors in human cells.

O-GlcNAc modification of nuclear pore complexes accelerates bi-directional transport

This study shows that O-GlcNAc modification of nuclear pore complexes enhances bidirectional nucleocytoplasmic transport by increasing FG-repeat barrier permeability.

Co-movement of astral microtubules, organelles and F-actin suggests aster positioning by surface forces in frog eggs

The paper observes co-movement of astral microtubules, organelles, and F-actin in Xenopus eggs, suggesting that surface forces, not dynein-based transport, drive aster positioning.

A tool for browsing the Cancer Dependency Map reveals functional connections between genes and helps predict the efficacy and selectivity of candidate cancer drugs

The paper introduces a user-friendly browser for the Cancer Dependency Map that predicts drug efficacy and selectivity based on gene dependencies in cancer cell lines.

Tubulin mRNA stability is sensitive to change in microtubule dynamics caused by multiple physiological and toxic cues

The paper shows that tubulin mRNA stability changes with microtubule dynamics, responding to various physiological and toxic cues, and proposes a new genomic approach to study microtubule regulation.

Physical basis of large microtubule aster growth

This study develops a biophysical model of microtubule aster growth that predicts traveling waves and explosive transitions, confirmed by experiments in frog egg extract.