A. I. Nesvizhskii

The paper compares HLA-B44 peptidomes with and without tapasin to show tapasin influences C-terminal tryptophan residues and peptide binding affinity.

This study determines the structure of autoinhibited kinesin-1 using XL-MS, EM, and AlphaFold, showing how light chains stabilize the inhibited state and how activation requires disrupting multiple domain interactions.

The paper shows Aurora B phosphorylates Keratin 8 at the cleavage furrow, facilitating its disassembly during cytokinesis in epithelial cancer cells.

The paper develops a computational workflow for glyco-immunopeptidomics, identifies glycosylated MHC class II peptides, and provides a resource with over 3,400 HLA class II N-glycopeptides.

The paper identifies secreted proteins by comparing their abundance in conditioned media and cell lysates, finding proteins enriched in media as potential secreted candidates.

This study determines the structural mechanism by which KIFBP remodels kinesin motors to block microtubule-binding, revealing a 2-pronged inhibition strategy.

This study shows GRASP55 promotes mutant huntingtin secretion via autophagy and stress conditions, reducing aggregation and toxicity.

The paper identifies thousands of novel cancer-specific antigens by analyzing PTMs in immunopeptidomics data from multiple sources and reveals their impact on HLA binding and TCR recognition.

This study shows viperin reduces cholesterol levels by inhibiting key enzymes in the biosynthetic pathway, though the exact mechanism remains unclear.