ESCRT disruption provides evidence against signaling functions for synaptic exosomes
E. C. Dresselhaus, K. P. Harris, C. R. R. Blanchette, K. Koles, S. J. Del Signore, M. F. Pescosolido, B. Ermanoska, M. Rozencwaig, R. C. Soslowsky, M. J. Parisi, B. A. Stewart, T. J. Mosca, A. A. Rodal
The paper shows that ESCRT disruption in Drosophila motor neurons affects EV cargo release but not their signaling activities, suggesting EVs may primarily serve proteostatic functions.
bioRxiv · Apr 22, 2023 · PreprintCell Biology