Inadvertent Transfer of Murine VL30 Retrotransposons to CAR-T Cells.
S. h. Lee, Y. Hao, T. Gui, G. Dotti, B. Savoldo, F. Zou, T. Kafri
This study shows that murine VL30 retrotransposons can be inadvertently transferred to CAR-T cells via γ-retroviral vectors, raising biosafety concerns.
bioRxiv · Feb 1, 2022Microbiology