Single cell characterization of B-lymphoid differentiation and leukemic cell states during chemotherapy in ETV6-RUNX1 positive pediatric leukemia identifies drug-targetable transcription factor activities
J. Mehtonen, S. Teppo, M. Lahnalampi, A. Kokko, R. Kaukonen, L. Oksa, M. Bouvy-Liivrand, A. Malyukova, S. Laukkanen, P. I. Makinen, S. Rounioja, P. Ruusuvuori, O. Sangfelt, R. Lund, T. Lonnberg, , M. Heinaniemi
This study uses scRNA-seq to analyze B-lymphoid differentiation and leukemic cell states in ETV6-RUNX1-positive pediatric leukemia, identifying drug-targetable transcription factor activities.
bioRxiv · May 27, 2020Cancer Biology