Author

J. Huuhtanen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:scRNA-seq· 3 Research Focus:cell type annotation· 2 Approach:deep learning· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2

Frequent Co-Authors

S. Mustjoki· 3 shared P. Ellonen· 2 shared A. Dumitrescu· 1 shared A. Jerez· 1 shared A. Kreutzman· 1 shared A. M. Hurtado· 1 shared A. Näätänen· 1 shared A. Riedel· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersImmunology

S. Mustjoki

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Author profile →

4 papers

Recent·Most cited

EPIC-TRACE: predicting TCR binding to unseen epitopes using attention and contextualized embeddings

D. Korpela, E. Jokinen, A. Dumitrescu, J. Huuhtanen, S. Mustjoki, H. Lähdesämki

EPIC-TRACE predicts TCR binding to unseen epitopes using attention mechanisms and contextualized embeddings, outperforming existing models.

bioRxiv · Jun 26, 2023Immunology

Single-cell functional genomics of natural killer cell evasion in blood cancers

O. Dufva, S. Gandolfi, J. Huuhtanen, O. Dashevsky, K. Saeed, J. Klievink, P. Nygren, J. Bouhlal, J. Lahtela, A. Näätänen, B. Ghimire, T. Hannunen, P. Ellonen, H. Duan, J. Theodoropoulos, , S. Mustjoki

The paper uses single-cell and genome-scale functional genomics to study how blood cancer cells evade NK cells, identifying key genes and pathways involved in resistance and sensitivity.

bioRxiv · Aug 22, 2022 · PreprintImmunology

Somatic Mutations in Clonally Expanded T-lymphocytes in Patients with Chronic Graft-Versus-Host Disease

G. Park, S. Mustjoki, D. Kim, J. Huuhtanen, S. Lundgren, R. K. Khajuria, A. M. Hurtado, C. Munoz-Calleja, L. Cardenoso, V. Gomez-Garcia de Soria, T. H. Chen-Liang, S. Eldfors, P. Ellonen, S. Hannula, O. Bruck, , M. A. I. Keranen

This study identifies somatic mutations in clonally expanded T-cells in chronic GvHD patients, showing they drive persistent activation and resistance to mTOR inhibitors.

bioRxiv · Aug 31, 2019 · PreprintImmunology

Single-cell RNA sequencing reveals a dynamic stromal niche within the evolving tumour microenvironment

S. Davidson, M. Efremova, A. Riedel, B. Mahata, J. Pramanik, J. Huuhtanen, G. Kar, R. Vento-Tormo, T. Hagai, X. Chen, M. A. Haniffa, J. D. Shields, S. A. Teichmann

This study uses single-cell RNA sequencing to analyze stromal cell changes in murine melanoma, identifying distinct CAF populations and their roles in immune suppression across tumor development.

bioRxiv · Nov 9, 2018 · PreprintCancer Biology