Spinocerebellar Ataxia Type 1 protein Ataxin-1 is signalled to DNA damage by Ataxia Telangiectasia Mutated kinase
C. E. Suart, A. M. Perez, I. Al-Ramahi, T. Maiuri, J. Botas, R. Truant
This study shows that ataxin-1 localizes to DNA damage sites and is phosphorylated by ATM kinase, with polyglutamine expansions impairing this response, suggesting a link between DNA repair and SCA1 pathogenesis.
bioRxiv · Sep 18, 2020Cell Biology