Functional mRNA delivery to hematopoietic stem and progenitor cells in vivo.
D. Alvarez, G. Masse-Ranson, S. K. Sedimbi, P. Wisti, L. Rodriguez, J. Santana, T. Manning, T. Towner, B. Geilich, C. Mihai, A. Mishra, S. Gurumurthy, J. Frederick, U. H. von Andrian, J. Hoggatt, , J. R. Mora
This study demonstrates in vivo delivery of functional mRNA to hematopoietic stem cells (HSC) using lipid nanoparticles, achieving transfection in ~25% of mouse HSC with potential for therapeutic applications.
bioRxiv · Dec 15, 2022 · PreprintImmunology