Mitochondrial fission is a critical modulator of mutant APP-induced neural toxicity
Lauren Y. Shields, Huihui Li, Kevin Nguyen, Hwajin Kim, Zak Doric, Joseph H. Garcia, T. Michael Gill, Dominik Haddad, Keith A. Vossel, Meredith Calvert, Ken Nakamura
This study shows that loss of Drp1 in neurons worsens memory deficits in mice with mutant hAPP, revealing a protective role of mitochondrial fission against hAPP-induced pathology.
Journal of Biological Chemistry · Jan 1, 2021Peer-reviewedNeuroscience