Zak Doric

This study shows that chronic hyperactivation of midbrain dopamine neurons leads to their preferential degeneration, suggesting increased neural activity may contribute to Parkinson's disease pathology.

This paper introduces GEDI, a fluorescent biosensor that detects early irreversible commitment to cell death in neurons, enabling real-time and high-throughput analysis of neurodegeneration.

This study shows that loss of Drp1 in neurons worsens memory deficits in mice with mutant hAPP, revealing a protective role of mitochondrial fission against hAPP-induced pathology.