Author

T. Ntombela

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:proteomics· 2 Approach:deep learning· 1 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

C. Gorgulla· 2 shared H. Arthanari· 2 shared J. Blavier· 2 shared J. Olivet· 2 shared J.-C. Twizere· 2 shared K. Salehi-Ashtiani· 2 shared S. Ballet· 2 shared S. Maseko· 2 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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2 shared papersBiochemistry

C. Gorgulla

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Author profile →

2 papers

Recent·Most cited

Identification of small molecule antivirals against HTLV-1 by targeting the hDLG1-Tax-1 protein-protein interaction

J.-C. Twizere, S. Maseko, Y. Brammerloo, I. Van.Molle, A. Sogues Castrejon, C. Martin, C. Gorgulla, J. Olivet, J. Blavier, T. Ntombela, D. Frank, H. Arthanari, H. Remaut, K. Salehi-Ashtiani, S. Ballet, O. Volkov

The paper identifies a small molecule that inhibits the Tax-1-hDLG1 interaction, reducing HTLV-1 cell-to-cell transmission in a T-cell model.

bioRxiv · Mar 15, 2023Biochemistry

Structural basis for targeting the human T-cell leukemia virus Tax oncoprotein and syntenin-1 interaction using a small molecule

S. Maseko, I. Van Molle, K. Blibek, C. Gorgulla, J. Olivet, J. Blavier, C. Vandermeulen, S. Skupiewski, D. Saha, T. Ntombela, J. Lim, F. Lembo, A. Beauvois, M. Hamaidia, J.-P. Borg, , J.-C. Twizere

This study identifies the structural basis of Tax-1 interaction with syntenin-1 and demonstrates small-molecule inhibition of this interaction to target HTLV-1.

bioRxiv · Aug 25, 2021 · PreprintBiochemistry