Author

J.-C. Twizere

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cell Biology· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 5 Assay:proteomics· 5 Research Focus:drug response / drug discovery· 3 Approach:deep learning· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

D. Saha· 3 shared D.-K. Kim· 3 shared J. Blavier· 3 shared J. Olivet· 3 shared K. Salehi-Ashtiani· 3 shared C. Gorgulla· 2 shared F. Dequiedt· 2 shared H. Arthanari· 2 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersMicrobiology

D. Saha

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

A comprehensive two-hybrid analysis to explore the L. pneumophila effector-effector interactome

H. O'Connor Mount, M. L. Urbanus, D. Sheykhkarimli, A. G. Cote, F. Laval, G. Coppin, N. Kishore, R. Li, K. Spirohn-Fitzgerald, M. O. Petersen, J. J. Knapp, D.-K. Kim, J.-C. Twizere, M. A. Calderwood, M. Vidal, , A. W. Ensminger

The paper uses a yeast two-hybrid screen to identify novel effector-effector interactions in L. pneumophila, doubling the known number of such interactions.

bioRxiv · Mar 29, 2024 · PreprintMicrobiology

Nanobodies against SARS-CoV-2 non-structural protein Nsp9 inhibit viral replication by targeting innate immunity

T. Venit, J. Blavier, S. B. Maseko, S. Shu, L. Espada, C. Breunig, H.-P. Holthoff, S. C. Desbordes, M. Lohse, G. Esposito, J.-C. Twizere, P. Percipalle

This paper designs nanobodies against SARS-CoV-2 Nsp9 to inhibit viral replication, showing effectiveness against multiple variants in HEK293-ACE2 cells.

bioRxiv · Oct 12, 2023 · PreprintCell Biology

A gut meta-interactome map reveals modulation of human immunity by microbiome effectors

V. Young, B. Dohai, T. C. Hitch, P. Hyden, B. Weller, N. S. Heusden, D. Saha, J. F. Macgregor, S. B. Maseko, C.-W. Lin, M. Boujeant, S. A. Choteau, F. Ober, P. Schwehn, S. Rothballer, , P. Falter-Braun

The paper identifies a gut microbiome meta-interactome map showing how bacterial effectors modulate human immunity and are enriched in Crohn's disease.

bioRxiv · Sep 25, 2023 · PreprintMicrobiology

Identification of small molecule antivirals against HTLV-1 by targeting the hDLG1-Tax-1 protein-protein interaction

J.-C. Twizere, S. Maseko, Y. Brammerloo, I. Van.Molle, A. Sogues Castrejon, C. Martin, C. Gorgulla, J. Olivet, J. Blavier, T. Ntombela, D. Frank, H. Arthanari, H. Remaut, K. Salehi-Ashtiani, S. Ballet, O. Volkov

The paper identifies a small molecule that inhibits the Tax-1-hDLG1 interaction, reducing HTLV-1 cell-to-cell transmission in a T-cell model.

bioRxiv · Mar 15, 2023Biochemistry

Structural basis for targeting the human T-cell leukemia virus Tax oncoprotein and syntenin-1 interaction using a small molecule

S. Maseko, I. Van Molle, K. Blibek, C. Gorgulla, J. Olivet, J. Blavier, C. Vandermeulen, S. Skupiewski, D. Saha, T. Ntombela, J. Lim, F. Lembo, A. Beauvois, M. Hamaidia, J.-P. Borg, , J.-C. Twizere

This study identifies the structural basis of Tax-1 interaction with syntenin-1 and demonstrates small-molecule inhibition of this interaction to target HTLV-1.

bioRxiv · Aug 25, 2021 · PreprintBiochemistry

Host PDZ-containing proteins targeted by SARS-Cov-2

C. Caillet-Saguy, F. Durbesson, V. V. REZELJ, G. Gogl, Q. D. Tran, J.-C. Twizere, M. Vignuzzi, R. Vincentelli, N. Wolff

The paper identifies sixteen human PDZ binders of SARS-CoV-2 proteins E, 3a, and N, showing significant interactions and potential roles in viral replication and immune evasion.

bioRxiv · Feb 1, 2021Biochemistry

Exostosin-1 Glycosyltransferase Regulates Endoplasmic Reticulum Architecture and Dynamics

D. Kerselidou, B. S. Dohai, D. R. Nelson, S. Daakour, N. De Cock, D.-K. Kim, J. Olivet, D. C. El Assal, A. Jaiswal, D. Saha, C. Pain, F. Matthijssens, P. Lemaitre, M. Herfs, J. Chapuis, , J.-C. Twizere

This study shows that Exostosin-1 glycosyltransferase regulates ER morphology and dynamics, affecting cell size and metabolic processes in mammalian cells.

bioRxiv · Sep 2, 2020 · PreprintCell Biology