Longitudinal clonal dynamics of HIV-1 latent reservoirs measured by combination quadruplex polymerase chain reaction and sequencing
A. Cho, C. Gaebler, T. Olveira, V. Ramos, M. Saad, J. Lorenzi, A. Gazumyan, S. Moir, T.-W. Chun, M. Caskey, M. Nussenzweig
This study uses Q4PCR to measure longitudinal changes in HIV-1 latent reservoirs, finding that intact proviruses decay faster than defective ones and show increased clonal expansion over time.
bioRxiv · Oct 28, 2021Immunology