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Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
24 papers
Recent·Most cited
F. Zhang, F. Schmidt, F. Muecksch, Z. Wang, A. Gazumyan, M. C. Nussenzweig, C. Gaebler, M. Caskey, T. Hatziioannou, P. D. Bieniasz
This study examines how SARS-CoV-2 spike glycosylation affects viral function and neutralization sensitivity to antibodies.
bioRxiv · Jun 30, 2023Microbiology
L. Witte, V. Baharani, F. Schmidt, Z. Wang, A. Cho, R. Raspe, M. C. Guzman-Cardozo, F. Muecksch, C. Gaebler, M. Caskey, M. C. Nussenzweig, T. Hatziioannou, P. D. Bieniasz
The paper shows that epistasis reduces the genetic barrier for SARS-CoV-2 variants to escape broadly neutralizing antibodies by enabling resistance through combinations of mutations.
bioRxiv · Aug 17, 2022Microbiology
Z. Wang, P. Zhou, F. Muecksch, A. Cho, T. B. Tanfous, M. Canis, L. Witte, B. Johnson, R. Raspe, F. Schmidt, E. Bednarski, J. DaSilva, V. Ramos, S. Zong, M. Turroja, , M. C. Nussenzweig
This study compares memory B cell responses after Delta and Omicron BA.1 breakthrough infections versus mRNA vaccine doses, finding that Delta infection boosts overall memory B cell potency and breadth, while Omicron infection only enhances strain-specific responses.
bioRxiv · Aug 11, 2022Immunology
Z. Wang, F. Muecksch, F. Muenn, A. Cho, S. Zong, R. Raspe, V. Ramos, B. Johnson, T. B. Tanfous, J. DaSilva, E. Bednarski, C. Guzman-Cardozo, P. Tober-Lau, D. Hillus, K. Yao, , C. Gaebler
This study compares humoral immune responses to different SARS-CoV-2 vaccination regimens, finding differences in antibody and memory B cell responses and neutralizing breadth against variants.
bioRxiv · May 13, 2022Immunology
A. Cho, F. Muecksch, Z. Wang, T. Ben Tanfous, J. DaSilva, R. Raspe, B. Johnson, E. Bednarski, V. Ramos, D. Schaefer-Babajew, I. Shimeliovich, J. Dizon, K.-H. Yao, F. Schmidt, K. G. Millard, , M. C. Nussenzweig
This study compares memory B cell responses after single-dose Ad26.COV2.S and mRNA vaccines, finding lower quantities but comparable neutralizing quality in Ad26.COV2.S recipients.
bioRxiv · Mar 31, 2022Immunology
F. Muecksch, Z. Wang, A. Cho, C. Gaebler, T. Ben Tanfous, J. DaSilva, E. Bednarski, V. Ramos, S. Zong, B. Johnson, R. Raspe, D. Schaefer-Babajew, I. Shimeliovich, M. Daga, K.-H. Yao, , M. Nussenzweig
This study shows that a third mRNA vaccine dose increases the potency and breadth of SARS-CoV-2 neutralizing antibodies, particularly against the Omicron variant, through the expansion and evolution of memory B cells.
bioRxiv · Feb 14, 2022 · PreprintImmunology
Z. Wang, F. Muecksch, A. Cho, C. Gaebler, H.-H. Hoffmann, V. Ramos, S. Zong, M. Cipolla, B. Johnson, F. Schmidt, J. DaSilva, E. Bednarski, T. B. Tanfous, R. Raspe, K. Yao, , M. C. Nussenzweig
The paper identifies conserved neutralizing epitopes on the N-terminal domain of SARS-CoV-2 spike proteins using NTD-specific probes and characterizes antibodies that neutralize multiple variants.
bioRxiv · Feb 1, 2022 · PreprintImmunology
A. Cho, C. Gaebler, T. Olveira, V. Ramos, M. Saad, J. Lorenzi, A. Gazumyan, S. Moir, T.-W. Chun, M. Caskey, M. Nussenzweig
This study uses Q4PCR to measure longitudinal changes in HIV-1 latent reservoirs, finding that intact proviruses decay faster than defective ones and show increased clonal expansion over time.
bioRxiv · Oct 28, 2021Immunology
F. Schmidt, Y. Weisblum, M. Rutkowska, D. Poston, J. Da Silva, F. Zhang, E. Bednarski, A. Cho, D. Schaefer-Babajew, C. Gaebler, M. Caskey, M. C. Nussenzweig, T. Hatziioannou, P. D. Bieniasz
This study shows that multiple neutralizing epitopes in SARS-CoV-2 spike proteins are targeted by polyclonal antibodies, and 20 mutations can confer resistance, but vaccinated and infected individuals' plasma neutralizes these resistant variants and diverse sarbecoviruses.
bioRxiv · Aug 6, 2021Microbiology
A. Cho, F. Muecksch, D. Schaefer-Babajew, Z. Wang, S. Finkin, C. Gaebler, V. Ramos, M. Cipolla, P. Mendoza, M. Agudelo, E. Bednarski, J. DaSilva, I. Shimeliovich, J. Dizon, M. Daga, , M. C. Nussenzweig
This study examines memory B cell evolution 5 months after mRNA vaccination in naive individuals, finding increased neutralizing activity but no further breadth or potency, and higher overall plasma neutralizing potency compared to natural infection.
bioRxiv · Jul 29, 2021Immunology
Z. Wang, F. Muecksch, D. Schaefer-Babajew, S. Finkin, C. Viant, C. Gaebler, H.- H. Hoffmann, C. O. Barnes, M. Cipolla, V. Ramos, T. Y. Oliveira, A. Cho, F. Schmidt, J. D. Silva, E. Bednarski, , M. C. Nussenzweig
This study shows that convalescent individuals with or without vaccination maintain neutralizing activity and memory B cells against SARS-CoV-2 for up to one year, with vaccination enhancing breadth and potency against variants.
Nature · Jun 14, 2021Peer-reviewedImmunology
A. J. Greaney, T. N. Starr, C. O. Barnes, Y. Weisblum, F. Schmidt, M. Caskey, C. Gaebler, M. Agudelo, S. Finkin, Z. Wang, D. Poston, F. Muecksch, T. Hatziioannou, P. D. Bieniasz, D. F. Robbiani, , J. D. Bloom
The paper maps mutations in SARS-CoV-2 spike RBD that escape binding by three antibody classes and finds that plasma escape maps closely resemble those of a single antibody class targeting site E484.
bioRxiv · Mar 17, 2021Microbiology
F. Muecksch, Y. Weisblum, C. Barnes, F. Schmidt, D. Schaefer-Babajew, J. Lorenzi, A. Flyak, A. DeLaitsch, K. Huey-Tubman, S. Hou, C. Schiffer, C. Gaebler, Z. Wang, J. Da Silva, D. Poston, , P. Bieniasz
This study examines how somatic mutations in SARS-CoV-2 antibodies affect their neutralization potency, breadth, and resistance to escape mutations across six antibody lineages.
bioRxiv · Mar 7, 2021 · PreprintMicrobiology
Z. Wang, F. Schmidt, Y. Weisblum, F. Muecksch, C. O. Barnes, S. Finkin, D. Schaefer-Babajew, M. Cipolla, C. Gaebler, J. A. Lieberman, T. Y. Oliveira, Z. Yang, M. E. Abernathy, K. E. Huey-Tubman, A. Hurley, , M. C. Nussenzweig
This study examines antibody and memory B cell responses to mRNA vaccines against SARS-CoV-2 and assesses their effectiveness against emerging variants.
Nature · Feb 10, 2021Peer-reviewedImmunology
G. Breton, P. Mendoza, T. Hagglof, T. Y. Oliveira, D. Schaefer-Babajew, C. Gaebler, M. Turroja, A. Hurley, M. Caskey, M. C. Nussenzweig
The paper shows that SARS-CoV-2 infection leads to persistent, functional memory T cell responses and enduring immune alterations in CD4+ and CD8+ T cells six months post-infection.
bioRxiv · Dec 8, 2020Immunology
C. Gaebler, Z. Wang, J. C. C. Lorenzi, F. Muecksch, S. Finkin, M. Tokuyama, A. Cho, M. Jankovic, D. Schaefer-Babajew, T. Y. Oliveira, M. Cipolla, C. Viant, C. O. Barnes, A. Hurley, M. Turroja, , R. Patel
This study examines the evolution of antibody immunity to SARS-CoV-2 over time, finding that memory B cells evolve with increased potency and resistance to mutations.
bioRxiv · Nov 3, 2020Immunology
C. Gaebler, S. D. Falcinelli, E. Stoffel, J. Read, R. Murtagh, T. Oliveira, V. Ramos, J. C. Lorenzi, J. L. Kirchherr, K. S. James, B. Allard, C. Baker, J. D. Kuruc, M. Caskey, N. Archin, , M. C. Nussenzweig
This study compares two novel assays, IPDA and Q4PCR, for measuring intact HIV proviral DNA in ART-suppressed individuals, finding significant differences in their frequency estimates.
bioRxiv · Oct 7, 2020Microbiology
Z. Wang, J. C. C. Lorenzi, F. Muecksch, S. Finkin, C. Viant, C. Gaebler, M. Cipolla, H.-H. Hoffman, T. Y. Oliveira, D. A. Oren, V. Ramos, L. Nogueira, E. Michailidis, D. F. Robbiani, A. Gazumyan, , M. C. Nussenzweig
This study shows that secretory IgA, particularly dimers, are more potent than IgG in neutralizing SARS-CoV-2 in vitro, suggesting their importance for mucosal protection and vaccine design.
bioRxiv · Sep 9, 2020 · PreprintImmunology
Y. Weisblum, F. Schmidt, F. Zhang, J. DaSilva, D. Poston, J. C. C. Lorenzi, F. Muecksch, M. Rutkowska, H.-H. Hoffmann, E. Michailidis, C. Gaebler, M. Agudelo, A. Cho, Z. Wang, A. Gazumyan, , P. D. Bieniasz
The paper shows SARS-CoV-2 variants resistant to neutralizing antibodies can be selected and are present in circulating populations, suggesting the need for combination antibody therapies.
bioRxiv · Jul 21, 2020Microbiology
F. Schmidt, Y. Weisblum, F. Muecksch, H.-H. Hoffmann, E. Michailidis, J. C. C. Lorenzi, P. Mendoza, M. Rutkowska, E. Bednarski, C. Gaebler, M. Agudelo, A. Cho, Z. Wang, A. Gazumyan, M. Cipolla, , P. D. Bieniasz
The paper describes assays using pseudotyped and chimeric viruses to measure SARS-CoV-2 neutralizing antibody activity, showing correlation with authentic assays.
bioRxiv · Jun 8, 2020Microbiology
C. O. Barnes, A. P. West, K. Huey-Tubman, M. A. G. Hoffmann, N. G. Sharaf, P. R. Hoffman, N. Koranda, H. B. Gristick, C. Gaebler, F. Muecksch, J. C. Cetrulo Lorenzi, S. Finkin, T. Hagglof, A. Hurley, K. G. Millard, , P. J. Bjorkman
bioRxiv · May 28, 2020Immunology
D. F. Robbiani, C. Gaebler, F. Muecksch, J. Cetrulo Lorenzi, Z. Wang, A. Cho, M. Agudelo, C. Barnes, S. Finkin, T. Hagglof, T. Oliveira, C. Viant, A. Hurley, K. Millard, R. Kost, , Nuss
The paper analyzes antibody responses in convalescent individuals, finding low neutralizing titers but rare potent RBD-specific antibodies with broad antiviral potential.
bioRxiv · May 13, 2020Immunology
P. Mendoza, J. R. Jackson, T. Oliveira, C. Gaebler, V. Ramos, M. Caskey, M. Jankovic, M. C. Nussenzweig, L. B. Cohn
The paper shows that antigen-responsive CD4+ T cell clones with latent HIV-1 proviruses persist in individuals, suggesting antigen exposure contributes to reservoir longevity.
bioRxiv · Jan 10, 2020Immunology