V. Ramos

CD4-binding site immunogens elicit heterologous anti-HIV-1 neutralizing antibodies in transgenic and wildtype animals

This study shows that CD4bs immunogens can elicit potent, broad anti-HIV-1 neutralizing antibodies in transgenic and wildtype animals.

Memory B cell responses to Omicron subvariants after SARS-CoV-2 mRNA breakthrough infection

This study compares memory B cell responses after Delta and Omicron BA.1 breakthrough infections versus mRNA vaccine doses, finding that Delta infection boosts overall memory B cell potency and breadth, while Omicron infection only enhances strain-specific responses.

Humoral immunity to SARS-CoV-2 elicited by combination COVID-19 vaccination regimens

This study compares humoral immune responses to different SARS-CoV-2 vaccination regimens, finding differences in antibody and memory B cell responses and neutralizing breadth against variants.

Antibody evolution to SARS-CoV-2 after single-dose Ad26.COV2.S vaccine

This study compares memory B cell responses after single-dose Ad26.COV2.S and mRNA vaccines, finding lower quantities but comparable neutralizing quality in Ad26.COV2.S recipients.

Distinct gene expression by expanded clones of quiescent memory CD4+ T cells harboring intact latent HIV-1 proviruses

Increased Potency and Breadth of SARS-CoV-2 Neutralizing Antibodies After a Third mRNA Vaccine Dose

This study shows that a third mRNA vaccine dose increases the potency and breadth of SARS-CoV-2 neutralizing antibodies, particularly against the Omicron variant, through the expansion and evolution of memory B cells.

Conserved Neutralizing Epitopes on the N-Terminal Domain of Variant SARS-CoV-2 Spike Proteins

The paper identifies conserved neutralizing epitopes on the N-terminal domain of SARS-CoV-2 spike proteins using NTD-specific probes and characterizes antibodies that neutralize multiple variants.

Longitudinal clonal dynamics of HIV-1 latent reservoirs measured by combination quadruplex polymerase chain reaction and sequencing

This study uses Q4PCR to measure longitudinal changes in HIV-1 latent reservoirs, finding that intact proviruses decay faster than defective ones and show increased clonal expansion over time.

Anti- SARS-CoV-2 Receptor Binding Domain Antibody Evolution after mRNA Vaccination

This study examines memory B cell evolution 5 months after mRNA vaccination in naive individuals, finding increased neutralizing activity but no further breadth or potency, and higher overall plasma neutralizing potency compared to natural infection.

Naturally enhanced neutralizing breadth to SARS-CoV-2 after one year

This study shows that convalescent individuals with or without vaccination maintain neutralizing activity and memory B cells against SARS-CoV-2 for up to one year, with vaccination enhancing breadth and potency against variants.

Establishment of the family Zarkiaceae (Oscillatoriales, Cyanobacteria) and description of the new marine genera Zarkia (Zarkiaceae, Oscillatoriales) and Romeriopsis (Leptolyngbyaceae, Synechococcales), from northern Portugal

The paper describes two new marine Cyanobacteria genera and a family, based on morphological and molecular data from strains isolated in northern Portugal.

Development of potency, breadth and resilience to viral escape mutations in SARS-CoV-2 neutralizing antibodies

This study examines how somatic mutations in SARS-CoV-2 antibodies affect their neutralization potency, breadth, and resistance to escape mutations across six antibody lineages.

mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants

This study examines antibody and memory B cell responses to mRNA vaccines against SARS-CoV-2 and assesses their effectiveness against emerging variants.

Evolution of Antibody Immunity to SARS-CoV-2

This study examines the evolution of antibody immunity to SARS-CoV-2 over time, finding that memory B cells evolve with increased potency and resistance to mutations.

Sequence evaluation and comparative analysis of novel assays for intact proviral HIV-1 DNA

This study compares two novel assays, IPDA and Q4PCR, for measuring intact HIV proviral DNA in ART-suppressed individuals, finding significant differences in their frequency estimates.

Enhanced SARS-CoV-2 Neutralization by Secretory IgA in vitro

This study shows that secretory IgA, particularly dimers, are more potent than IgG in neutralizing SARS-CoV-2 in vitro, suggesting their importance for mucosal protection and vaccine design.

A Broadly Neutralizing Macaque Monoclonal Antibody Against the HIV-1 V3-Glycan Patch

This paper reports a broadly neutralizing monoclonal antibody from a macaque infected with SHIVAD8 that targets the V3-glycan patch of HIV-1 Env, showing neutralizing activity and protective efficacy in vivo.

Convergent Antibody Responses to SARS-CoV-2 Infection in Convalescent Individuals

The paper analyzes antibody responses in convalescent individuals, finding low neutralizing titers but rare potent RBD-specific antibodies with broad antiviral potential.

Antigen responsive CD4+ T cell clones contribute to the HIV-1 latent reservoir

The paper shows that antigen-responsive CD4+ T cell clones with latent HIV-1 proviruses persist in individuals, suggesting antigen exposure contributes to reservoir longevity.