Author

T. P. Woerner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1

Frequent Co-Authors

A. J. R. Heck· 4 shared J. Snijder· 4 shared M. Agbandje-McKenna· 2 shared T. W. Powers· 2 shared A. A. Makarov· 1 shared A. Bennett· 1 shared A. D. Bennett· 1 shared A. Makarov· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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4 shared papersBiochemistry

A. J. R. Heck

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Author profile →

4 papers

Recent·Most cited

Assessment of genome packaging in AAVs using Orbitrap-based charge detection mass spectrometry

T. P. Woerner, J. Snijder, O. Friese, T. W. Powers, A. J. R. Heck

This paper introduces a method using Orbitrap-based charge detection mass spectrometry to rapidly and sensitively quantify AAV genome packaging, improving bioprocessing and drug development.

bioRxiv · Sep 2, 2021Biochemistry

Frequency chasing of individual megadalton ions in an Orbitrap analyzer improves precision of analysis in single molecule mass spectrometry

T. P. Woerner, K. Aizikov, J. Snijder, K. L. Fort, A. A. Makarov, A. J. R. Heck

This study improves mass spectrometry precision by tracking ion frequency drift in high-mass ions, achieving better resolution and sampling through desolvation correction.

bioRxiv · Jun 15, 2021Biophysics

Adeno-associated virus capsid assembly is divergent and stochastic

T. P. Woerner, A. Bennett, S. Habka, J. Snijder, O. V. Friese, T. W. Powers, M. Agbandje-McKenna, A. J. R. Heck

This study reveals that AAV capsid assembly is highly stochastic and heterogeneous, with each capsid having a unique composition.

bioRxiv · Oct 9, 2020Biochemistry

Resolving heterogeneous high-mass macromolecular machineries by Orbitrap-based single particle charge detection mass spectrometry

A. J. R. Heck, T. P. Woerner, J. Snijder, A. D. Bennett, M. Agbandje-McKenna, A. Makarov

This paper demonstrates that Orbitrap-based single particle charge detection mass spectrometry can resolve high-mass heterogeneous biomolecular assemblies by accurately predicting charge states and masses.

bioRxiv · Jul 28, 2019 · PreprintBiophysics