A. Makarov

Evaluating the performance of the Astral mass analyzer for quantitative proteomics using data independent acquisition

The paper evaluates the Astral mass analyzer's performance in quantitative proteomics, showing it quantifies 5 times more peptides per unit time than existing Orbitrap mass spectrometers and detects over 5,000 plasma proteins.

Parallelized Acquisition of Orbitrap and Astral Analyzers Enables High-Throughput Quantitative Analysis.

The paper introduces a new hybrid mass spectrometer combining Orbitrap and Astral analyzers to enable faster and more sensitive high-resolution accurate mass MS/MS spectra acquisition for proteomics.

Scanning ion-conductance microscopy for studying β-amyloid aggregate formation on living cell surface

This study uses scanning ion-conductance microscopy to investigate how β-amyloid aggregates affect the mechanical properties of living cells.

Structural remodeling of SARS-CoV-2 spike protein glycans reveals the regulatory roles in receptor binding affinity

This study investigates how glycosylation of the SARS-CoV-2 spike protein affects receptor binding affinity through glycoengineering and molecular analysis.

A Compact Quadrupole-Orbitrap Mass Spectrometer with FAIMS Interface Improves Proteome Coverage in Short LC Gradients

Resolving heterogeneous high-mass macromolecular machineries by Orbitrap-based single particle charge detection mass spectrometry

This paper demonstrates that Orbitrap-based single particle charge detection mass spectrometry can resolve high-mass heterogeneous biomolecular assemblies by accurately predicting charge states and masses.

Limits for resolving tandem mass tag reporter ions with identical integer mass using phase constrained spectrum deconvolution

The paper determines the mass resolution limits for resolving TMT reporter ions with 0.0063 Da mass differences using an Orbitrap mass spectrometer.