Author

T. R. Holman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:cryo-EM· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

M. Holinstat· 2 shared A. Glukhova· 1 shared B. E. Tourdot· 1 shared C. Kalyanaraman· 1 shared D. M. Thal· 1 shared H. Venugopal· 1 shared J. C. Freedman· 1 shared J. I. Mobbs· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiochemistry

M. Holinstat

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Author profile →

2 papers

Recent·Most cited

Cryo-EM structures of human arachidonate 12S-Lipoxygenase (12-LOX) bound to endogenous and exogenous inhibitors

J. I. Mobbs, K. A. Black, M. Tran, H. Venugopal, T. R. Holman, M. Holinstat, D. M. Thal, A. Glukhova

This study determines the cryo-EM structures of human 12-LOX, revealing its oligomeric states, catalytic mechanism, and inhibitor binding, which informs drug development.

bioRxiv · Mar 10, 2023Biochemistry

Altered specificity of 15-LOX-1 in the biosynthesis of 7S,14S-diHDHA implicates 15-LOX-2 in biosynthesis of resolvin D5

S. C. Perry, C. Kalyanaraman, B. E. Tourdot, W. S. Conrad, O. Akinkugbe, J. C. Freedman, M. Holinstat, M. P. Jacobson, T. R. Holman

This paper identifies that h15-LOX-2 preferentially produces RvD5 from 7S-HDHA with faster kinetics than h15-LOX-1, suggesting a greater role for h15-LOX-2 in biosynthesizing resolvin D5.

bioRxiv · Mar 25, 2020Biochemistry