Author

J. I. Mobbs

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:protein structure prediction· 2 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. Glukhova· 3 shared D. M. Thal· 3 shared H. Venugopal· 2 shared A. Bhattarai· 1 shared A. Christopoulos· 1 shared A. Tobin· 1 shared C. Valant· 1 shared C. W. Lindsley· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersPharmacology & Toxicology

A. Glukhova

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Author profile →

3 papers

Recent·Most cited

Structural insights into the human P2X1 receptor and ligand interactions

F. Bennetts, H. Venugopal, A. Glukhova, J. I. Mobbs, S. Ventura, D. M. Thal

This study determines the structure of the human P2X1 receptor in different ligand-bound states and identifies key residues involved in ligand binding and selectivity.

bioRxiv · Apr 4, 2024Pharmacology & Toxicology

Cryo-EM structures of human arachidonate 12S-Lipoxygenase (12-LOX) bound to endogenous and exogenous inhibitors

J. I. Mobbs, K. A. Black, M. Tran, H. Venugopal, T. R. Holman, M. Holinstat, D. M. Thal, A. Glukhova

This study determines the cryo-EM structures of human 12-LOX, revealing its oligomeric states, catalytic mechanism, and inhibitor binding, which informs drug development.

bioRxiv · Mar 10, 2023Biochemistry

Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics

Z. Vuckovic, J. Wang, V. Pham, J. I. Mobbs, M. J. Belousoff, A. Bhattarai, W. A. C. Burger, G. Thompson, M. Yeasmin, K. Leach, E. T. van der Westhuizen, E. Khajehali, Y.-L. Liang, A. Glukhova, D. Wootten, , D. M. Thal

The paper presents cryo-EM structures of the M4 mAChR with ligands and modulators, revealing structural and dynamic insights into allosteric modulation and receptor activation mechanisms.

bioRxiv · Sep 27, 2022Pharmacology & Toxicology