T. R. Sosnick

An adaptive biomolecular condensation response is conserved across environmentally divergent species

The paper studies how stress-induced biomolecular condensation adapts to thermal environments across three yeast species, showing species-specific temperature tuning and conserved molecular features.

LILAC: Enhanced actin imaging with an optogenetic Lifeact

The paper introduces an optogenetic Lifeact variant for enhanced actin imaging, allowing light-controlled binding to reduce background and avoid cell perturbations.

HDX-MS performed on BtuB in E. coli outer membranes delineates the luminal domain's allostery and unfolding upon B12 and TonB binding

This study uses HDX-MS on BtuB in E. coli outer membranes to show B12 binding destabilizes the Ionic Lock, while TonB binding has weaker effects and no pore formation is observed.

Commonly-used FRET fluorophores promote collapse of an otherwise disordered protein.

The paper shows that FRET fluorophores can cause disordered proteins to contract, explaining discrepancies between FRET and SAXS measurements of unfolded proteins.

Investigations of human myosin VI targeting using optogenetically-controlled cargo loading

This paper develops an optogenetic tool to control myosin VI activation with high spatial and temporal resolution, revealing how it integrates multiple signals for site-specific function.