Author

J. A. Riback

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 5

Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:chromatin & epigenetic regulation· 2 Assay:imaging· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

C. P. brangwynne· 3 shared D. S. W. Lee· 2 shared D. W. Sanders· 2 shared L. Beckers· 2 shared A. M. Zmyslowski· 1 shared C.-H. Choi· 1 shared D. A. Drummond· 1 shared D. Kahan· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersBiophysics

C. P. brangwynne

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5 papers

Recent·Most cited

Sequential Activation and Local Unfolding Control Poly(A)-Binding Protein Condensation

R. Chen, D. Kahan, J. Shangguan, J. R. Sachleben, J. A. Riback, D. A. Drummond, T. Sosnick

This study uses HDX-MS to reveal that Pab1 condensation involves sequential activation of its RRMs through partial unfolding, driven by thermodynamic specificity.

bioRxiv · Sep 21, 2022 · PreprintBiophysics

A rich get richer effect governs intracellular condensate size distributions

D. S. W. Lee, C.-H. Choi, D. W. Sanders, L. Beckers, J. A. Riback, C. P. brangwynne, N. S. Wingreen

The paper investigates condensate size distributions in cells and finds that exponential and power-law distributions arise from different physical mechanisms, with the latter linked to a 'rich get richer' effect.

bioRxiv · Mar 8, 2022 · PreprintBiophysics

Viscoelastic RNA entanglement and advective flow underlie nucleolar form and function

J. A. Riback, J. M. Eeftens, D. S. W. Lee, S. A. Quinodoz, L. Beckers, L. A. Becker, C. P. Brangwynne

The paper maps nucleolar rRNA dynamics using imaging and modeling, finding that rRNA moves radially due to viscoelastic properties and polymerization, leading to a new model for rRNA release.

bioRxiv · Dec 31, 2021Biophysics

Composition dependent phase separation underlies directional flux through the nucleolus

J. A. Riback, L. Zhu, M. C. Ferrolino, M. Tolbert, D. M. Mitrea, D. W. Sanders, M.-T. Wei, R. W. Kriwacki, C. P. Brangwynne

This study shows that heterotypic interactions drive nucleolar phase separation without a fixed saturation concentration, revealing a thermodynamic framework for condensate composition and function.

bioRxiv · Oct 22, 2019Biophysics

Commonly-used FRET fluorophores promote collapse of an otherwise disordered protein.

J. A. Riback, M. A. Bowman, A. M. Zmyslowski, K. W. Plaxco, P. L. Clark, T. R. Sosnick

The paper shows that FRET fluorophores can cause disordered proteins to contract, explaining discrepancies between FRET and SAXS measurements of unfolded proteins.

bioRxiv · Oct 31, 2018Biophysics