Microglia-neuron communication at nodes of Ranvier depends on neuronal activity through potassium release and contributes to myelin repair.
Rémi Ronzano, T. Roux, Melina Thétiot, Marie‐Stéphane Aigrot, Laurence Richard, François‐Xavier Lejeune, Elisa Mazuir, Jean‐Michel Vallat, Catherine Lubetzki, Anne Desmazières
This study identifies nodes of Ranvier as a site of microglia-axon interaction, showing that neuronal activity and potassium release influence microglia behavior and myelin repair.
Nature Communications · Sep 1, 2021Peer-reviewedNeuroscience