Rémi Ronzano

Spinal circuit regionalization diversifies motor output along the vertebrate body axis

This study constructs a cross-species spinal interneuron atlas and shows that Hox-dependent regionalization of circuits drives motor output diversity across vertebrate body regions.

Spinal circuits encode a map of the trunk to control skin twitches

The paper identifies spinal circuits that map trunk regions to control skin twitches in mice, showing somatotopic organization and optogenetic activation of specific motor pathways.

Neuronal activity promotes repair by microglial reprogramming following demyelination

This study shows neuronal activity drives microglial reprogramming toward a pro-regenerative state during remyelination in MS models, altering gene expression related to oxidative phosphorylation and lipid metabolism.

Intrinsic spinal cord circuits compare sensory inputs and efference copies to correct for perturbations to ongoing movement

This study identifies dI3 neurons in the spinal cord that compare efference copies and sensory feedback to enable rapid movement corrections.

Neuronal activity promotes axonal node-like clustering prior to myelination and remyelination in the central nervous system.

This study shows neuronal activity promotes node-like clustering before myelination and remyelination, with glutamatergic signaling and Nav1.1 expression playing key roles.

Spinal premotor interneurons controlling antagonistic muscles are spatially intermingled

The paper investigates the spatial organization of spinal premotor interneurons controlling flexor and extensor muscles, finding they are intermingled rather than segregated.

Spinal neurons innervating multiple local and distant motor pools

The paper investigates spinal neurons that project to multiple motor pools, showing they coordinate activity across joints and mediate co-contraction of antagonist muscles.

Microglia-neuron communication at nodes of Ranvier depends on neuronal activity through potassium release and contributes to myelin repair.

This study identifies nodes of Ranvier as a site of microglia-axon interaction, showing that neuronal activity and potassium release influence microglia behavior and myelin repair.