Catherine Lubetzki

The paper identifies high neuron-microglia interaction at the node of Ranvier as a predictor of recovery in an inflammatory MS model, showing its association with pro-regenerative microglia and improved tissue repair.

This study shows neuronal activity drives microglial reprogramming toward a pro-regenerative state during remyelination in MS models, altering gene expression related to oxidative phosphorylation and lipid metabolism.

This study shows neuronal activity promotes node-like clustering before myelination and remyelination, with glutamatergic signaling and Nav1.1 expression playing key roles.

This study shows that genetically-modified macrophages can deliver Sema3F to demyelinating lesions, increasing OPC recruitment and accelerating remyelination in mice.

The paper investigates axon initial segment alterations in multiple sclerosis, finding increased soma-axon initial segment gap in both active and inactive lesions.

This study identifies nodes of Ranvier as a site of microglia-axon interaction, showing that neuronal activity and potassium release influence microglia behavior and myelin repair.

The paper shows that oligodendrocyte secreted factors influence hippocampal GABAergic neuron transcriptome and physiology by modulating gene expression and synaptic activity.

The paper identifies an alternative mechanism for early nodal clustering and myelination onset in GABAergic neurons through live imaging and molecular analysis.