François‐Xavier Lejeune

This study shows that spontaneous slow waves in Disorders of Consciousness patients correlate with recovery potential and residual awareness, challenging the view of slow waves as merely a marker of impaired consciousness.

This study uses optical genome mapping to analyze C9orf72 repeat expansion instability in blood from ALS and FTD patients, finding age-dependent differences in repeat size dynamics between conditions.

The paper examines how diet and genetic factors affect metabolomics and microbiota in a Down syndrome mouse model, identifying interactions that influence metabolic pathways.

The paper identifies high neuron-microglia interaction at the node of Ranvier as a predictor of recovery in an inflammatory MS model, showing its association with pro-regenerative microglia and improved tissue repair.

The paper investigates cerebellar neuromodulatory networks involved in motor adaptation and reinforcement feedback using PET and fMRI data, finding distinct roles for serotonin and dopamine in adaptation speed and retention.

This study shows neuronal activity drives microglial reprogramming toward a pro-regenerative state during remyelination in MS models, altering gene expression related to oxidative phosphorylation and lipid metabolism.

The paper uses NM-sensitive MRI to study neuromelanin accumulation and neurodegeneration in Parkinson's disease models, finding a biphasic signal change linked to a pathogenic threshold.

This study investigates network alterations in olfactory dysfunction in Parkinson's disease and iRBD patients using multimodal MRI, finding correlations between olfactory function and specific brain regions and networks.

The paper shows that the UPRER coordinates mitochondrial stress responses in human dopaminergic neurons, including mitophagy and lncRNA expression, and identifies a lncRNA involved in translation resumption.

This study shows neuronal activity promotes node-like clustering before myelination and remyelination, with glutamatergic signaling and Nav1.1 expression playing key roles.

This study generates Sspo knockout mice and finds reduced brain ventricle size but only minor spine curvature defects.

This study shows zebrafish lateral line hair cells detect serotonin, influencing navigation behavior in response to environmental cues.

This study investigates error-monitoring failure in early Alzheimer's disease patients with subjective memory complaints, linking it to anosognosia.

This study identifies nodes of Ranvier as a site of microglia-axon interaction, showing that neuronal activity and potassium release influence microglia behavior and myelin repair.

This paper identifies that rostral spinal sensory neurons synapse onto hindbrain motor neurons and reticulospinal neurons, enhancing locomotor speed and postural control.

The paper identifies two voltage-dependent currents that regulate the functional diversity and developmental trajectory of embryonic Renshaw cells.

The paper identifies an alternative mechanism for early nodal clustering and myelination onset in GABAergic neurons through live imaging and molecular analysis.

The paper shows that Reissner fiber is critical for CSF-contacting neurons to detect spinal curvature in zebrafish larvae.